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Design, Synthesis, Biological Activities and 3D-QSAR of New N,N'-Diacylhydrazines Containing 2,4-Dichlorophenoxy Moieties

A series of new N,N'-diacylhydrazine derivatives were designed and synthesized. Their structures were verified by (1)H-NMR, MS and elemental analysis. The herbicidal activities and plant growth regulating activity of these N,N'-diacylhydrazines were evaluated. The herbicidal activity resul...

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Detalles Bibliográficos
Autores principales: Sun, Guo-Xiang, Sun, Zhao-Hui, Yang, Ming-Yan, Liu, Xing-Hai, Ma, Yi, Wei, Yun-Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270310/
https://www.ncbi.nlm.nih.gov/pubmed/24300121
http://dx.doi.org/10.3390/molecules181214876
Descripción
Sumario:A series of new N,N'-diacylhydrazine derivatives were designed and synthesized. Their structures were verified by (1)H-NMR, MS and elemental analysis. The herbicidal activities and plant growth regulating activity of these N,N'-diacylhydrazines were evaluated. The herbicidal activity results showed that most of these N,N'-diacyl-hydrazines showed excellent in vivo activities against Echinochloa crus-galli, Digitaria sanguinalis, Brassica napus, Amaranthus retroflerus. Most of them exhibited higher herbicidal activities against dicotyledonous weeds than monocotyledonous weeds. To further investigate the structure-activity relationship, comparative molecular field analysis (CoMFA) was performed on the basis of herbicidal activity data. Both the steric and electronic field distributions of CoMFA are in good agreement in this work.