Cargando…

Maternal High Fat Feeding Does Not Have Long-Lasting Effects on Body Composition and Bone Health in Female and Male Wistar Rat Offspring at Young Adulthood

High fat diets adversely affect body composition, bone mineral and strength, and alter bone fatty acid composition. It is unclear if maternal high fat (HF) feeding permanently alters offspring body composition and bone health. Female rats were fed control (CON) or HF diet for 10 weeks, bred, and con...

Descripción completa

Detalles Bibliográficos
Autores principales: Miotto, Paula M., Castelli, Laura M., Amoye, Foyinsola, LeBlanc, Paul J., Peters, Sandra J., Roy, Brian D., Ward, Wendy E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270313/
https://www.ncbi.nlm.nih.gov/pubmed/24322493
http://dx.doi.org/10.3390/molecules181215094
_version_ 1783376670694047744
author Miotto, Paula M.
Castelli, Laura M.
Amoye, Foyinsola
LeBlanc, Paul J.
Peters, Sandra J.
Roy, Brian D.
Ward, Wendy E.
author_facet Miotto, Paula M.
Castelli, Laura M.
Amoye, Foyinsola
LeBlanc, Paul J.
Peters, Sandra J.
Roy, Brian D.
Ward, Wendy E.
author_sort Miotto, Paula M.
collection PubMed
description High fat diets adversely affect body composition, bone mineral and strength, and alter bone fatty acid composition. It is unclear if maternal high fat (HF) feeding permanently alters offspring body composition and bone health. Female rats were fed control (CON) or HF diet for 10 weeks, bred, and continued their diets throughout pregnancy and lactation. Male and female offspring were studied at weaning and 3 months, following consumption of CON diet. At weaning, but not 3 months of age, male and female offspring from dams fed HF diet had lower lean mass and higher fat and bone mass, and higher femur bone mineral density (females only) than offspring of dams fed CON diet. Male and female offspring femurs from dams fed HF diet had higher monounsaturates and lower n6 polyunsaturates at weaning than offspring from dams fed CON diet, where females from dams fed HF diet had higher saturates and lower n6 polyunsaturates at 3 months of age. There were no differences in strength of femurs or lumbar vertebrae at 3 months of age in either male or female offspring. In conclusion, maternal HF feeding did not permanently affect body composition and bone health at young adulthood in offspring.
format Online
Article
Text
id pubmed-6270313
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-62703132018-12-20 Maternal High Fat Feeding Does Not Have Long-Lasting Effects on Body Composition and Bone Health in Female and Male Wistar Rat Offspring at Young Adulthood Miotto, Paula M. Castelli, Laura M. Amoye, Foyinsola LeBlanc, Paul J. Peters, Sandra J. Roy, Brian D. Ward, Wendy E. Molecules Article High fat diets adversely affect body composition, bone mineral and strength, and alter bone fatty acid composition. It is unclear if maternal high fat (HF) feeding permanently alters offspring body composition and bone health. Female rats were fed control (CON) or HF diet for 10 weeks, bred, and continued their diets throughout pregnancy and lactation. Male and female offspring were studied at weaning and 3 months, following consumption of CON diet. At weaning, but not 3 months of age, male and female offspring from dams fed HF diet had lower lean mass and higher fat and bone mass, and higher femur bone mineral density (females only) than offspring of dams fed CON diet. Male and female offspring femurs from dams fed HF diet had higher monounsaturates and lower n6 polyunsaturates at weaning than offspring from dams fed CON diet, where females from dams fed HF diet had higher saturates and lower n6 polyunsaturates at 3 months of age. There were no differences in strength of femurs or lumbar vertebrae at 3 months of age in either male or female offspring. In conclusion, maternal HF feeding did not permanently affect body composition and bone health at young adulthood in offspring. MDPI 2013-12-06 /pmc/articles/PMC6270313/ /pubmed/24322493 http://dx.doi.org/10.3390/molecules181215094 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Miotto, Paula M.
Castelli, Laura M.
Amoye, Foyinsola
LeBlanc, Paul J.
Peters, Sandra J.
Roy, Brian D.
Ward, Wendy E.
Maternal High Fat Feeding Does Not Have Long-Lasting Effects on Body Composition and Bone Health in Female and Male Wistar Rat Offspring at Young Adulthood
title Maternal High Fat Feeding Does Not Have Long-Lasting Effects on Body Composition and Bone Health in Female and Male Wistar Rat Offspring at Young Adulthood
title_full Maternal High Fat Feeding Does Not Have Long-Lasting Effects on Body Composition and Bone Health in Female and Male Wistar Rat Offspring at Young Adulthood
title_fullStr Maternal High Fat Feeding Does Not Have Long-Lasting Effects on Body Composition and Bone Health in Female and Male Wistar Rat Offspring at Young Adulthood
title_full_unstemmed Maternal High Fat Feeding Does Not Have Long-Lasting Effects on Body Composition and Bone Health in Female and Male Wistar Rat Offspring at Young Adulthood
title_short Maternal High Fat Feeding Does Not Have Long-Lasting Effects on Body Composition and Bone Health in Female and Male Wistar Rat Offspring at Young Adulthood
title_sort maternal high fat feeding does not have long-lasting effects on body composition and bone health in female and male wistar rat offspring at young adulthood
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270313/
https://www.ncbi.nlm.nih.gov/pubmed/24322493
http://dx.doi.org/10.3390/molecules181215094
work_keys_str_mv AT miottopaulam maternalhighfatfeedingdoesnothavelonglastingeffectsonbodycompositionandbonehealthinfemaleandmalewistarratoffspringatyoungadulthood
AT castellilauram maternalhighfatfeedingdoesnothavelonglastingeffectsonbodycompositionandbonehealthinfemaleandmalewistarratoffspringatyoungadulthood
AT amoyefoyinsola maternalhighfatfeedingdoesnothavelonglastingeffectsonbodycompositionandbonehealthinfemaleandmalewistarratoffspringatyoungadulthood
AT leblancpaulj maternalhighfatfeedingdoesnothavelonglastingeffectsonbodycompositionandbonehealthinfemaleandmalewistarratoffspringatyoungadulthood
AT peterssandraj maternalhighfatfeedingdoesnothavelonglastingeffectsonbodycompositionandbonehealthinfemaleandmalewistarratoffspringatyoungadulthood
AT roybriand maternalhighfatfeedingdoesnothavelonglastingeffectsonbodycompositionandbonehealthinfemaleandmalewistarratoffspringatyoungadulthood
AT wardwendye maternalhighfatfeedingdoesnothavelonglastingeffectsonbodycompositionandbonehealthinfemaleandmalewistarratoffspringatyoungadulthood