One-Pot Tandem Synthesis of 2-Arylquinazolines by a Multicomponent Cyclization Reaction

A series of 2-arylquinazolines have been synthesized in moderate to excellent yields by one-pot tandem reaction of (2-aminophenyl)methanols, aldehydes and ceric ammonium nitrate (CAN). The utility of this transformation was demonstrated by its compatibility with a wide range of functional groups. Th...

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Detalles Bibliográficos
Autores principales: Ye, Leping, Yu, Lin, Zhu, Lijun, Xia, Xiaodong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270323/
https://www.ncbi.nlm.nih.gov/pubmed/24217327
http://dx.doi.org/10.3390/molecules181113860
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author Ye, Leping
Yu, Lin
Zhu, Lijun
Xia, Xiaodong
author_facet Ye, Leping
Yu, Lin
Zhu, Lijun
Xia, Xiaodong
author_sort Ye, Leping
collection PubMed
description A series of 2-arylquinazolines have been synthesized in moderate to excellent yields by one-pot tandem reaction of (2-aminophenyl)methanols, aldehydes and ceric ammonium nitrate (CAN). The utility of this transformation was demonstrated by its compatibility with a wide range of functional groups. Thus, the method represents a simple and practical procedure to access 2-arylquinazolines.
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spelling pubmed-62703232018-12-20 One-Pot Tandem Synthesis of 2-Arylquinazolines by a Multicomponent Cyclization Reaction Ye, Leping Yu, Lin Zhu, Lijun Xia, Xiaodong Molecules Article A series of 2-arylquinazolines have been synthesized in moderate to excellent yields by one-pot tandem reaction of (2-aminophenyl)methanols, aldehydes and ceric ammonium nitrate (CAN). The utility of this transformation was demonstrated by its compatibility with a wide range of functional groups. Thus, the method represents a simple and practical procedure to access 2-arylquinazolines. MDPI 2013-11-08 /pmc/articles/PMC6270323/ /pubmed/24217327 http://dx.doi.org/10.3390/molecules181113860 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Ye, Leping
Yu, Lin
Zhu, Lijun
Xia, Xiaodong
One-Pot Tandem Synthesis of 2-Arylquinazolines by a Multicomponent Cyclization Reaction
title One-Pot Tandem Synthesis of 2-Arylquinazolines by a Multicomponent Cyclization Reaction
title_full One-Pot Tandem Synthesis of 2-Arylquinazolines by a Multicomponent Cyclization Reaction
title_fullStr One-Pot Tandem Synthesis of 2-Arylquinazolines by a Multicomponent Cyclization Reaction
title_full_unstemmed One-Pot Tandem Synthesis of 2-Arylquinazolines by a Multicomponent Cyclization Reaction
title_short One-Pot Tandem Synthesis of 2-Arylquinazolines by a Multicomponent Cyclization Reaction
title_sort one-pot tandem synthesis of 2-arylquinazolines by a multicomponent cyclization reaction
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270323/
https://www.ncbi.nlm.nih.gov/pubmed/24217327
http://dx.doi.org/10.3390/molecules181113860
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AT zhulijun onepottandemsynthesisof2arylquinazolinesbyamulticomponentcyclizationreaction
AT xiaxiaodong onepottandemsynthesisof2arylquinazolinesbyamulticomponentcyclizationreaction

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