Dihydrochalcones with Antiinflammatory Activity from Leaves and Twigs of Cyathostemma argenteum

A new dihydrochalcone derivative, 4',6'-dihydroxy-2',4-dimethoxy-5'-(2''-hydroxybenzyl)dihydrochalcone (1) and one known dihydrochalcone, 4',6'-dihydroxy-2',4- dimethoxydihydrochalcone (2) were isolated from leaves and twigs of Cyathostemma argenteum. The...

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Autores principales: Somsrisa, Jariya, Meepowpan, Puttinan, Krachodnok, Samroeng, Thaisuchat, Haruthai, Punyanitya, Sittiporn, Nantasaen, Narong, Pompimon, Wilart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270333/
https://www.ncbi.nlm.nih.gov/pubmed/23752472
http://dx.doi.org/10.3390/molecules18066898
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author Somsrisa, Jariya
Meepowpan, Puttinan
Krachodnok, Samroeng
Thaisuchat, Haruthai
Punyanitya, Sittiporn
Nantasaen, Narong
Pompimon, Wilart
author_facet Somsrisa, Jariya
Meepowpan, Puttinan
Krachodnok, Samroeng
Thaisuchat, Haruthai
Punyanitya, Sittiporn
Nantasaen, Narong
Pompimon, Wilart
author_sort Somsrisa, Jariya
collection PubMed
description A new dihydrochalcone derivative, 4',6'-dihydroxy-2',4-dimethoxy-5'-(2''-hydroxybenzyl)dihydrochalcone (1) and one known dihydrochalcone, 4',6'-dihydroxy-2',4- dimethoxydihydrochalcone (2) were isolated from leaves and twigs of Cyathostemma argenteum. Their structures were established by spectral methods, mainly 2D NMR spectroscopic techniques, which involved combined applications of DEPT, COSY, HMQC and HMBC. The molecular structure of 1 was also confirmed by single crystal X-ray diffraction. The test compounds 1 and 2 displayed significant inhibitory activity at a dose of 1 mg/ear on edema formation at all determination times, with similar intensity as phenylbutazone.
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spelling pubmed-62703332018-12-17 Dihydrochalcones with Antiinflammatory Activity from Leaves and Twigs of Cyathostemma argenteum Somsrisa, Jariya Meepowpan, Puttinan Krachodnok, Samroeng Thaisuchat, Haruthai Punyanitya, Sittiporn Nantasaen, Narong Pompimon, Wilart Molecules Article A new dihydrochalcone derivative, 4',6'-dihydroxy-2',4-dimethoxy-5'-(2''-hydroxybenzyl)dihydrochalcone (1) and one known dihydrochalcone, 4',6'-dihydroxy-2',4- dimethoxydihydrochalcone (2) were isolated from leaves and twigs of Cyathostemma argenteum. Their structures were established by spectral methods, mainly 2D NMR spectroscopic techniques, which involved combined applications of DEPT, COSY, HMQC and HMBC. The molecular structure of 1 was also confirmed by single crystal X-ray diffraction. The test compounds 1 and 2 displayed significant inhibitory activity at a dose of 1 mg/ear on edema formation at all determination times, with similar intensity as phenylbutazone. MDPI 2013-06-10 /pmc/articles/PMC6270333/ /pubmed/23752472 http://dx.doi.org/10.3390/molecules18066898 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Somsrisa, Jariya
Meepowpan, Puttinan
Krachodnok, Samroeng
Thaisuchat, Haruthai
Punyanitya, Sittiporn
Nantasaen, Narong
Pompimon, Wilart
Dihydrochalcones with Antiinflammatory Activity from Leaves and Twigs of Cyathostemma argenteum
title Dihydrochalcones with Antiinflammatory Activity from Leaves and Twigs of Cyathostemma argenteum
title_full Dihydrochalcones with Antiinflammatory Activity from Leaves and Twigs of Cyathostemma argenteum
title_fullStr Dihydrochalcones with Antiinflammatory Activity from Leaves and Twigs of Cyathostemma argenteum
title_full_unstemmed Dihydrochalcones with Antiinflammatory Activity from Leaves and Twigs of Cyathostemma argenteum
title_short Dihydrochalcones with Antiinflammatory Activity from Leaves and Twigs of Cyathostemma argenteum
title_sort dihydrochalcones with antiinflammatory activity from leaves and twigs of cyathostemma argenteum
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270333/
https://www.ncbi.nlm.nih.gov/pubmed/23752472
http://dx.doi.org/10.3390/molecules18066898
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