Uncarilic Acid and Secouncarilic Acid, Two New Triterpenoids from Uucaria sessilifructus

Two new compounds, the 6-oxo oleanane-type triterpenoid uncarilic acid, and its 5,6-secotriterpenoid derivative, secouncarilic acid, were isolated from the hooks and stems of Uucaria sessilifructus together with seven known ursane-type triterpenoids. Uncarilic acid is the second 6-oxo oleanane-type...

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Autores principales: Zhang, Mao-Juan, Liu, Bing, Liao, Shang-Gao, Xu, You-Kai, Feng, De-Qiang, Ji, Kai-Long, Li, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270339/
https://www.ncbi.nlm.nih.gov/pubmed/23948713
http://dx.doi.org/10.3390/molecules18089727
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author Zhang, Mao-Juan
Liu, Bing
Liao, Shang-Gao
Xu, You-Kai
Feng, De-Qiang
Ji, Kai-Long
Li, Yan
author_facet Zhang, Mao-Juan
Liu, Bing
Liao, Shang-Gao
Xu, You-Kai
Feng, De-Qiang
Ji, Kai-Long
Li, Yan
author_sort Zhang, Mao-Juan
collection PubMed
description Two new compounds, the 6-oxo oleanane-type triterpenoid uncarilic acid, and its 5,6-secotriterpenoid derivative, secouncarilic acid, were isolated from the hooks and stems of Uucaria sessilifructus together with seven known ursane-type triterpenoids. Uncarilic acid is the second 6-oxo oleanane-type triterpenoid ever reported, while secouncarilic acid is the first oleanane-type 5,6-secotriterpenoid. A plausible biosynthetic pathway from uncarilic acid to secouncarilic acid was also postulated. The inhibitory activities of all the nine compounds against LPS-induced nitric oxide production in RAW264.7 macrophages were evaluated.
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spelling pubmed-62703392018-12-18 Uncarilic Acid and Secouncarilic Acid, Two New Triterpenoids from Uucaria sessilifructus Zhang, Mao-Juan Liu, Bing Liao, Shang-Gao Xu, You-Kai Feng, De-Qiang Ji, Kai-Long Li, Yan Molecules Article Two new compounds, the 6-oxo oleanane-type triterpenoid uncarilic acid, and its 5,6-secotriterpenoid derivative, secouncarilic acid, were isolated from the hooks and stems of Uucaria sessilifructus together with seven known ursane-type triterpenoids. Uncarilic acid is the second 6-oxo oleanane-type triterpenoid ever reported, while secouncarilic acid is the first oleanane-type 5,6-secotriterpenoid. A plausible biosynthetic pathway from uncarilic acid to secouncarilic acid was also postulated. The inhibitory activities of all the nine compounds against LPS-induced nitric oxide production in RAW264.7 macrophages were evaluated. MDPI 2013-08-14 /pmc/articles/PMC6270339/ /pubmed/23948713 http://dx.doi.org/10.3390/molecules18089727 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Zhang, Mao-Juan
Liu, Bing
Liao, Shang-Gao
Xu, You-Kai
Feng, De-Qiang
Ji, Kai-Long
Li, Yan
Uncarilic Acid and Secouncarilic Acid, Two New Triterpenoids from Uucaria sessilifructus
title Uncarilic Acid and Secouncarilic Acid, Two New Triterpenoids from Uucaria sessilifructus
title_full Uncarilic Acid and Secouncarilic Acid, Two New Triterpenoids from Uucaria sessilifructus
title_fullStr Uncarilic Acid and Secouncarilic Acid, Two New Triterpenoids from Uucaria sessilifructus
title_full_unstemmed Uncarilic Acid and Secouncarilic Acid, Two New Triterpenoids from Uucaria sessilifructus
title_short Uncarilic Acid and Secouncarilic Acid, Two New Triterpenoids from Uucaria sessilifructus
title_sort uncarilic acid and secouncarilic acid, two new triterpenoids from uucaria sessilifructus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270339/
https://www.ncbi.nlm.nih.gov/pubmed/23948713
http://dx.doi.org/10.3390/molecules18089727
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