Three New Ursane-Type Triterpenoids from the Stems of Saprosma merrillii

Three new ursane-type triterpenoids, 3α,6α,30-trihydroxy-ursan-28-oic acid (1), 3α,30-dihydroxy-6-oxo-ursan-28-oic acid (2) and 3α,6α,7α,30-tetrahydroxy-ursan-28-oic acid (3), together with one known triterpenoid, betulinic acid (4), one known anthraquinone, 1,7-dihydroxy-2-methylanthraquinone (5),...

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Autores principales: Zhang, Dashuai, Chen, Wenhao, Chen, Wenxing, Song, Xiaoping, Han, Changri, Wang, Yan, Chen, Guangying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270353/
https://www.ncbi.nlm.nih.gov/pubmed/24287986
http://dx.doi.org/10.3390/molecules181214496
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author Zhang, Dashuai
Chen, Wenhao
Chen, Wenxing
Song, Xiaoping
Han, Changri
Wang, Yan
Chen, Guangying
author_facet Zhang, Dashuai
Chen, Wenhao
Chen, Wenxing
Song, Xiaoping
Han, Changri
Wang, Yan
Chen, Guangying
author_sort Zhang, Dashuai
collection PubMed
description Three new ursane-type triterpenoids, 3α,6α,30-trihydroxy-ursan-28-oic acid (1), 3α,30-dihydroxy-6-oxo-ursan-28-oic acid (2) and 3α,6α,7α,30-tetrahydroxy-ursan-28-oic acid (3), together with one known triterpenoid, betulinic acid (4), one known anthraquinone, 1,7-dihydroxy-2-methylanthraquinone (5), four known phenols, 1,3,5-trimethoxybenzene (6), p-hydroxybenzoic acid (7), syringic acid (8), isovanillin (9), two steroids, sitosterol (10) and daucosterol (11), were isolated from the ethanol extract of the stems of S. merrillii. Their structures were elucidated on the basis of physical and spectral techniques, besides comparison with literature data. Compounds 1–3 showed inhibitory activities against the A549, HEPG2, and B16F10 cell lines.
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spelling pubmed-62703532018-12-20 Three New Ursane-Type Triterpenoids from the Stems of Saprosma merrillii Zhang, Dashuai Chen, Wenhao Chen, Wenxing Song, Xiaoping Han, Changri Wang, Yan Chen, Guangying Molecules Article Three new ursane-type triterpenoids, 3α,6α,30-trihydroxy-ursan-28-oic acid (1), 3α,30-dihydroxy-6-oxo-ursan-28-oic acid (2) and 3α,6α,7α,30-tetrahydroxy-ursan-28-oic acid (3), together with one known triterpenoid, betulinic acid (4), one known anthraquinone, 1,7-dihydroxy-2-methylanthraquinone (5), four known phenols, 1,3,5-trimethoxybenzene (6), p-hydroxybenzoic acid (7), syringic acid (8), isovanillin (9), two steroids, sitosterol (10) and daucosterol (11), were isolated from the ethanol extract of the stems of S. merrillii. Their structures were elucidated on the basis of physical and spectral techniques, besides comparison with literature data. Compounds 1–3 showed inhibitory activities against the A549, HEPG2, and B16F10 cell lines. MDPI 2013-11-25 /pmc/articles/PMC6270353/ /pubmed/24287986 http://dx.doi.org/10.3390/molecules181214496 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Zhang, Dashuai
Chen, Wenhao
Chen, Wenxing
Song, Xiaoping
Han, Changri
Wang, Yan
Chen, Guangying
Three New Ursane-Type Triterpenoids from the Stems of Saprosma merrillii
title Three New Ursane-Type Triterpenoids from the Stems of Saprosma merrillii
title_full Three New Ursane-Type Triterpenoids from the Stems of Saprosma merrillii
title_fullStr Three New Ursane-Type Triterpenoids from the Stems of Saprosma merrillii
title_full_unstemmed Three New Ursane-Type Triterpenoids from the Stems of Saprosma merrillii
title_short Three New Ursane-Type Triterpenoids from the Stems of Saprosma merrillii
title_sort three new ursane-type triterpenoids from the stems of saprosma merrillii
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270353/
https://www.ncbi.nlm.nih.gov/pubmed/24287986
http://dx.doi.org/10.3390/molecules181214496
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