Bioactive Protopanaxatriol Type Saponins Isolated from the Roots of Panax Notoginseng (Burk.) F. H. Chen

Seven new protopanaxatriol type saponins, 20S-sanchirhinosides A(1) (1), A(2) (2), A(3) (3), A(4) (4), A(5) (5), and A(6) (6), and sanchirhinoside B (7) were obtained as minor constituents from the root extract of Panax notoginseng (Burkill, F. H. Chen), which showed protection effects against antim...

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Detalles Bibliográficos
Autores principales: Zhang, Yi, Han, Li-Feng, Sakah, Kaunda Joseph, Wu, Zhi-Zhen, Liu, Li-Li, Agyemang, Kojo, Gao, Xiu-Mei, Wang, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270354/
https://www.ncbi.nlm.nih.gov/pubmed/24064450
http://dx.doi.org/10.3390/molecules180910352
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author Zhang, Yi
Han, Li-Feng
Sakah, Kaunda Joseph
Wu, Zhi-Zhen
Liu, Li-Li
Agyemang, Kojo
Gao, Xiu-Mei
Wang, Tao
author_facet Zhang, Yi
Han, Li-Feng
Sakah, Kaunda Joseph
Wu, Zhi-Zhen
Liu, Li-Li
Agyemang, Kojo
Gao, Xiu-Mei
Wang, Tao
author_sort Zhang, Yi
collection PubMed
description Seven new protopanaxatriol type saponins, 20S-sanchirhinosides A(1) (1), A(2) (2), A(3) (3), A(4) (4), A(5) (5), and A(6) (6), and sanchirhinoside B (7) were obtained as minor constituents from the root extract of Panax notoginseng (Burkill, F. H. Chen), which showed protection effects against antimycin A induced mitochondrial oxidative stress. Their structures were elucidated by chemical and spectroscopic methods (IR, HRESI-TOF-MS, 1D and 2D NMR). Among them, compounds 4, 6 and 7 showed significant protective effects against antimycin A-induced L6 cell injury.
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spelling pubmed-62703542018-12-18 Bioactive Protopanaxatriol Type Saponins Isolated from the Roots of Panax Notoginseng (Burk.) F. H. Chen Zhang, Yi Han, Li-Feng Sakah, Kaunda Joseph Wu, Zhi-Zhen Liu, Li-Li Agyemang, Kojo Gao, Xiu-Mei Wang, Tao Molecules Article Seven new protopanaxatriol type saponins, 20S-sanchirhinosides A(1) (1), A(2) (2), A(3) (3), A(4) (4), A(5) (5), and A(6) (6), and sanchirhinoside B (7) were obtained as minor constituents from the root extract of Panax notoginseng (Burkill, F. H. Chen), which showed protection effects against antimycin A induced mitochondrial oxidative stress. Their structures were elucidated by chemical and spectroscopic methods (IR, HRESI-TOF-MS, 1D and 2D NMR). Among them, compounds 4, 6 and 7 showed significant protective effects against antimycin A-induced L6 cell injury. MDPI 2013-08-26 /pmc/articles/PMC6270354/ /pubmed/24064450 http://dx.doi.org/10.3390/molecules180910352 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Zhang, Yi
Han, Li-Feng
Sakah, Kaunda Joseph
Wu, Zhi-Zhen
Liu, Li-Li
Agyemang, Kojo
Gao, Xiu-Mei
Wang, Tao
Bioactive Protopanaxatriol Type Saponins Isolated from the Roots of Panax Notoginseng (Burk.) F. H. Chen
title Bioactive Protopanaxatriol Type Saponins Isolated from the Roots of Panax Notoginseng (Burk.) F. H. Chen
title_full Bioactive Protopanaxatriol Type Saponins Isolated from the Roots of Panax Notoginseng (Burk.) F. H. Chen
title_fullStr Bioactive Protopanaxatriol Type Saponins Isolated from the Roots of Panax Notoginseng (Burk.) F. H. Chen
title_full_unstemmed Bioactive Protopanaxatriol Type Saponins Isolated from the Roots of Panax Notoginseng (Burk.) F. H. Chen
title_short Bioactive Protopanaxatriol Type Saponins Isolated from the Roots of Panax Notoginseng (Burk.) F. H. Chen
title_sort bioactive protopanaxatriol type saponins isolated from the roots of panax notoginseng (burk.) f. h. chen
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270354/
https://www.ncbi.nlm.nih.gov/pubmed/24064450
http://dx.doi.org/10.3390/molecules180910352
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