Preparation, Purification and Regioselective Functionalization of Protoescigenin—The Main Aglycone of Escin Complex

A two-step chemical process for controlled degradation of escin, affording a mixture of olean-12-ene sapogenins, was elaborated and scaled up. The main component of the mixture—protoescigenin—was isolated and purified, in the form of its corresponding monohydrate, without resource to chromatographic...

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Autores principales: Gruza, Mariusz M., Jatczak, Kamil, Zagrodzki, Bogdan, Łaszcz, Marta, Koziak, Katarzyna, Malińska, Maura, Cmoch, Piotr, Giller, Tomasz, Zegrocka-Stendel, Oliwia, Woźniak, Krzysztof, Grynkiewicz, Grzegorz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270381/
https://www.ncbi.nlm.nih.gov/pubmed/23591921
http://dx.doi.org/10.3390/molecules18044389
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author Gruza, Mariusz M.
Jatczak, Kamil
Zagrodzki, Bogdan
Łaszcz, Marta
Koziak, Katarzyna
Malińska, Maura
Cmoch, Piotr
Giller, Tomasz
Zegrocka-Stendel, Oliwia
Woźniak, Krzysztof
Grynkiewicz, Grzegorz
author_facet Gruza, Mariusz M.
Jatczak, Kamil
Zagrodzki, Bogdan
Łaszcz, Marta
Koziak, Katarzyna
Malińska, Maura
Cmoch, Piotr
Giller, Tomasz
Zegrocka-Stendel, Oliwia
Woźniak, Krzysztof
Grynkiewicz, Grzegorz
author_sort Gruza, Mariusz M.
collection PubMed
description A two-step chemical process for controlled degradation of escin, affording a mixture of olean-12-ene sapogenins, was elaborated and scaled up. The main component of the mixture—protoescigenin—was isolated and purified, in the form of its corresponding monohydrate, without resource to chromatographic methods. This material was further converted into the high purity 3,24;16,22-di-O,O-isopropylidene derivative in a validated large scale laboratory process.
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spelling pubmed-62703812018-12-14 Preparation, Purification and Regioselective Functionalization of Protoescigenin—The Main Aglycone of Escin Complex Gruza, Mariusz M. Jatczak, Kamil Zagrodzki, Bogdan Łaszcz, Marta Koziak, Katarzyna Malińska, Maura Cmoch, Piotr Giller, Tomasz Zegrocka-Stendel, Oliwia Woźniak, Krzysztof Grynkiewicz, Grzegorz Molecules Article A two-step chemical process for controlled degradation of escin, affording a mixture of olean-12-ene sapogenins, was elaborated and scaled up. The main component of the mixture—protoescigenin—was isolated and purified, in the form of its corresponding monohydrate, without resource to chromatographic methods. This material was further converted into the high purity 3,24;16,22-di-O,O-isopropylidene derivative in a validated large scale laboratory process. MDPI 2013-04-15 /pmc/articles/PMC6270381/ /pubmed/23591921 http://dx.doi.org/10.3390/molecules18044389 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Gruza, Mariusz M.
Jatczak, Kamil
Zagrodzki, Bogdan
Łaszcz, Marta
Koziak, Katarzyna
Malińska, Maura
Cmoch, Piotr
Giller, Tomasz
Zegrocka-Stendel, Oliwia
Woźniak, Krzysztof
Grynkiewicz, Grzegorz
Preparation, Purification and Regioselective Functionalization of Protoescigenin—The Main Aglycone of Escin Complex
title Preparation, Purification and Regioselective Functionalization of Protoescigenin—The Main Aglycone of Escin Complex
title_full Preparation, Purification and Regioselective Functionalization of Protoescigenin—The Main Aglycone of Escin Complex
title_fullStr Preparation, Purification and Regioselective Functionalization of Protoescigenin—The Main Aglycone of Escin Complex
title_full_unstemmed Preparation, Purification and Regioselective Functionalization of Protoescigenin—The Main Aglycone of Escin Complex
title_short Preparation, Purification and Regioselective Functionalization of Protoescigenin—The Main Aglycone of Escin Complex
title_sort preparation, purification and regioselective functionalization of protoescigenin—the main aglycone of escin complex
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270381/
https://www.ncbi.nlm.nih.gov/pubmed/23591921
http://dx.doi.org/10.3390/molecules18044389
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