A Fully Automated Radiosynthesis of [(18)F]Fluoroethyl-Diprenorphine on a Single Module by Use of SPE Cartridges for Preparation of High Quality 2-[(18)F]Fluoroethyl Tosylate

We have developed a new method for automated production of 2-[(18)F]fluoroethyl tosylate ([(18)F]FETos) that enables (18)F-alkylation to provide PET tracers with high chemical purity. The method is based on the removal of excess ethylene glycol bistosylate precursor by precipitation and subsequent f...

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Detalles Bibliográficos
Autores principales: Schoultz, Bent W., Reed, Brian J., Marton, János, Willoch, Frode, Henriksen, Gjermund
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270389/
https://www.ncbi.nlm.nih.gov/pubmed/23787515
http://dx.doi.org/10.3390/molecules18067271
Descripción
Sumario:We have developed a new method for automated production of 2-[(18)F]fluoroethyl tosylate ([(18)F]FETos) that enables (18)F-alkylation to provide PET tracers with high chemical purity. The method is based on the removal of excess ethylene glycol bistosylate precursor by precipitation and subsequent filtration and purification of the filtrate by means of solid phase extraction cartridges (SPE). The method is integrated to a single synthesis module and thereby provides the advantage over previous methods of not requiring HPLC purification, as demonstrated by the full radiosynthesis of the potent opioid receptor PET tracer [(18)F]fluoroethyldiprenorphine.

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