Triterpenoids and Steroids from Ganoderma mastoporum and Their Inhibitory Effects on Superoxide Anion Generation and Elastase Release

The methanol extracts of the fruiting bodies of Ganoderma mastoporum collected in Vietnam was purified to afford eight compounds, including three triterpenoids and five steroids. The purified compounds were examined for their inhibitory effects against superoxide anion generation and elastase releas...

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Autores principales: Thang, Tran Dinh, Kuo, Ping-Chung, Hwang, Tsong-Long, Yang, Mei-Lin, Ngoc, Nguyen Thi Bich, Han, Tran Thi Ngoc, Lin, Chi-Wen, Wu, Tian-Shung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270410/
https://www.ncbi.nlm.nih.gov/pubmed/24256922
http://dx.doi.org/10.3390/molecules181114285
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author Thang, Tran Dinh
Kuo, Ping-Chung
Hwang, Tsong-Long
Yang, Mei-Lin
Ngoc, Nguyen Thi Bich
Han, Tran Thi Ngoc
Lin, Chi-Wen
Wu, Tian-Shung
author_facet Thang, Tran Dinh
Kuo, Ping-Chung
Hwang, Tsong-Long
Yang, Mei-Lin
Ngoc, Nguyen Thi Bich
Han, Tran Thi Ngoc
Lin, Chi-Wen
Wu, Tian-Shung
author_sort Thang, Tran Dinh
collection PubMed
description The methanol extracts of the fruiting bodies of Ganoderma mastoporum collected in Vietnam was purified to afford eight compounds, including three triterpenoids and five steroids. The purified compounds were examined for their inhibitory effects against superoxide anion generation and elastase release. Among the tested compounds, ergosta-4,6,8(14),22-tetraen-3-one (3) exhibited the most significant inhibition towards superoxide anion generation and elastase release with IC(50) values of 2.30 ± 0.38 and 1.94 ± 0.50 µg/mL, respectively.
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spelling pubmed-62704102018-12-20 Triterpenoids and Steroids from Ganoderma mastoporum and Their Inhibitory Effects on Superoxide Anion Generation and Elastase Release Thang, Tran Dinh Kuo, Ping-Chung Hwang, Tsong-Long Yang, Mei-Lin Ngoc, Nguyen Thi Bich Han, Tran Thi Ngoc Lin, Chi-Wen Wu, Tian-Shung Molecules Article The methanol extracts of the fruiting bodies of Ganoderma mastoporum collected in Vietnam was purified to afford eight compounds, including three triterpenoids and five steroids. The purified compounds were examined for their inhibitory effects against superoxide anion generation and elastase release. Among the tested compounds, ergosta-4,6,8(14),22-tetraen-3-one (3) exhibited the most significant inhibition towards superoxide anion generation and elastase release with IC(50) values of 2.30 ± 0.38 and 1.94 ± 0.50 µg/mL, respectively. MDPI 2013-11-19 /pmc/articles/PMC6270410/ /pubmed/24256922 http://dx.doi.org/10.3390/molecules181114285 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Thang, Tran Dinh
Kuo, Ping-Chung
Hwang, Tsong-Long
Yang, Mei-Lin
Ngoc, Nguyen Thi Bich
Han, Tran Thi Ngoc
Lin, Chi-Wen
Wu, Tian-Shung
Triterpenoids and Steroids from Ganoderma mastoporum and Their Inhibitory Effects on Superoxide Anion Generation and Elastase Release
title Triterpenoids and Steroids from Ganoderma mastoporum and Their Inhibitory Effects on Superoxide Anion Generation and Elastase Release
title_full Triterpenoids and Steroids from Ganoderma mastoporum and Their Inhibitory Effects on Superoxide Anion Generation and Elastase Release
title_fullStr Triterpenoids and Steroids from Ganoderma mastoporum and Their Inhibitory Effects on Superoxide Anion Generation and Elastase Release
title_full_unstemmed Triterpenoids and Steroids from Ganoderma mastoporum and Their Inhibitory Effects on Superoxide Anion Generation and Elastase Release
title_short Triterpenoids and Steroids from Ganoderma mastoporum and Their Inhibitory Effects on Superoxide Anion Generation and Elastase Release
title_sort triterpenoids and steroids from ganoderma mastoporum and their inhibitory effects on superoxide anion generation and elastase release
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270410/
https://www.ncbi.nlm.nih.gov/pubmed/24256922
http://dx.doi.org/10.3390/molecules181114285
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