Synthesis of 3,4-Dibenzyltetrahydrofuran Lignans (9,9′-Epoxylignanes)

Different strategies for the racemic or enantiospecific total syntheses of plant and mammalian 3,4-dibenzyltetrahydrofuran lignans are reviewed and compared. The multi-step approaches have various key step strategies: Diels–Alder reactions, Stobbe condensations, Michael additions, alkylations, nitri...

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Detalles Bibliográficos
Autores principales: Pohjoispää, Monika, Wähälä, Kristiina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270424/
https://www.ncbi.nlm.nih.gov/pubmed/24284480
http://dx.doi.org/10.3390/molecules181113124
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author Pohjoispää, Monika
Wähälä, Kristiina
author_facet Pohjoispää, Monika
Wähälä, Kristiina
author_sort Pohjoispää, Monika
collection PubMed
description Different strategies for the racemic or enantiospecific total syntheses of plant and mammalian 3,4-dibenzyltetrahydrofuran lignans are reviewed and compared. The multi-step approaches have various key step strategies: Diels–Alder reactions, Stobbe condensations, Michael additions, alkylations, nitrile oxide cycloadditions, radical cyclisations, dianion and oxidative couplings.
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spelling pubmed-62704242018-12-20 Synthesis of 3,4-Dibenzyltetrahydrofuran Lignans (9,9′-Epoxylignanes) Pohjoispää, Monika Wähälä, Kristiina Molecules Review Different strategies for the racemic or enantiospecific total syntheses of plant and mammalian 3,4-dibenzyltetrahydrofuran lignans are reviewed and compared. The multi-step approaches have various key step strategies: Diels–Alder reactions, Stobbe condensations, Michael additions, alkylations, nitrile oxide cycloadditions, radical cyclisations, dianion and oxidative couplings. MDPI 2013-10-24 /pmc/articles/PMC6270424/ /pubmed/24284480 http://dx.doi.org/10.3390/molecules181113124 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Pohjoispää, Monika
Wähälä, Kristiina
Synthesis of 3,4-Dibenzyltetrahydrofuran Lignans (9,9′-Epoxylignanes)
title Synthesis of 3,4-Dibenzyltetrahydrofuran Lignans (9,9′-Epoxylignanes)
title_full Synthesis of 3,4-Dibenzyltetrahydrofuran Lignans (9,9′-Epoxylignanes)
title_fullStr Synthesis of 3,4-Dibenzyltetrahydrofuran Lignans (9,9′-Epoxylignanes)
title_full_unstemmed Synthesis of 3,4-Dibenzyltetrahydrofuran Lignans (9,9′-Epoxylignanes)
title_short Synthesis of 3,4-Dibenzyltetrahydrofuran Lignans (9,9′-Epoxylignanes)
title_sort synthesis of 3,4-dibenzyltetrahydrofuran lignans (9,9′-epoxylignanes)
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270424/
https://www.ncbi.nlm.nih.gov/pubmed/24284480
http://dx.doi.org/10.3390/molecules181113124
work_keys_str_mv AT pohjoispaamonika synthesisof34dibenzyltetrahydrofuranlignans99epoxylignanes
AT wahalakristiina synthesisof34dibenzyltetrahydrofuranlignans99epoxylignanes

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