A Bicyclic Diterpenoid with a New 15,16-Dinorlabdane Carbon Skeleton from Leonurus japonicus and Its Coagulant Bioactivity

A new 15,16-dinorlabdane diterpenoid 1 and a known labdane diterpenoid 2, together with three known ergosterols 3–5, were isolated from the EtOAc-soluble portion of the EtOH extract of Leonurus japonicus. Their structures were elucidated by physical and spectroscopic analysis. Compound 1 showed in v...

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Detalles Bibliográficos
Autores principales: Peng, Fu, Xiong, Liang, Zhao, Xiao-Mei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270439/
https://www.ncbi.nlm.nih.gov/pubmed/24284488
http://dx.doi.org/10.3390/molecules181113904
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author Peng, Fu
Xiong, Liang
Zhao, Xiao-Mei
author_facet Peng, Fu
Xiong, Liang
Zhao, Xiao-Mei
author_sort Peng, Fu
collection PubMed
description A new 15,16-dinorlabdane diterpenoid 1 and a known labdane diterpenoid 2, together with three known ergosterols 3–5, were isolated from the EtOAc-soluble portion of the EtOH extract of Leonurus japonicus. Their structures were elucidated by physical and spectroscopic analysis. Compound 1 showed in vitro coagulant activity in the APTT, PT, TT, and FIB assays.
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spelling pubmed-62704392018-12-20 A Bicyclic Diterpenoid with a New 15,16-Dinorlabdane Carbon Skeleton from Leonurus japonicus and Its Coagulant Bioactivity Peng, Fu Xiong, Liang Zhao, Xiao-Mei Molecules Communication A new 15,16-dinorlabdane diterpenoid 1 and a known labdane diterpenoid 2, together with three known ergosterols 3–5, were isolated from the EtOAc-soluble portion of the EtOH extract of Leonurus japonicus. Their structures were elucidated by physical and spectroscopic analysis. Compound 1 showed in vitro coagulant activity in the APTT, PT, TT, and FIB assays. MDPI 2013-11-11 /pmc/articles/PMC6270439/ /pubmed/24284488 http://dx.doi.org/10.3390/molecules181113904 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Communication
Peng, Fu
Xiong, Liang
Zhao, Xiao-Mei
A Bicyclic Diterpenoid with a New 15,16-Dinorlabdane Carbon Skeleton from Leonurus japonicus and Its Coagulant Bioactivity
title A Bicyclic Diterpenoid with a New 15,16-Dinorlabdane Carbon Skeleton from Leonurus japonicus and Its Coagulant Bioactivity
title_full A Bicyclic Diterpenoid with a New 15,16-Dinorlabdane Carbon Skeleton from Leonurus japonicus and Its Coagulant Bioactivity
title_fullStr A Bicyclic Diterpenoid with a New 15,16-Dinorlabdane Carbon Skeleton from Leonurus japonicus and Its Coagulant Bioactivity
title_full_unstemmed A Bicyclic Diterpenoid with a New 15,16-Dinorlabdane Carbon Skeleton from Leonurus japonicus and Its Coagulant Bioactivity
title_short A Bicyclic Diterpenoid with a New 15,16-Dinorlabdane Carbon Skeleton from Leonurus japonicus and Its Coagulant Bioactivity
title_sort bicyclic diterpenoid with a new 15,16-dinorlabdane carbon skeleton from leonurus japonicus and its coagulant bioactivity
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270439/
https://www.ncbi.nlm.nih.gov/pubmed/24284488
http://dx.doi.org/10.3390/molecules181113904
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