Synthesis of Esters of Ginsenoside Metabolite M1 and Their Cytotoxicity on MGC80-3 Cells

Monoesters of ginsenoside metabolite M1 at the 3-OH, 4-OH and 6-OH positions of the glucose moiety at M1 were synthesized via the reaction of M1 with acyl chloride, or acid-N,N'-diisopropylcarbodiimide in the presence of DMAP. Their structures were fully characterized by spectral methods. The c...

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Detalles Bibliográficos
Autores principales: Li, Wen-Fang, Chen, Li-Rong, Gong, Xiao-Jie, Li, Zheng-Ning, Li, Ke-Ke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270463/
https://www.ncbi.nlm.nih.gov/pubmed/23529029
http://dx.doi.org/10.3390/molecules18043689
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author Li, Wen-Fang
Chen, Li-Rong
Gong, Xiao-Jie
Li, Zheng-Ning
Li, Ke-Ke
author_facet Li, Wen-Fang
Chen, Li-Rong
Gong, Xiao-Jie
Li, Zheng-Ning
Li, Ke-Ke
author_sort Li, Wen-Fang
collection PubMed
description Monoesters of ginsenoside metabolite M1 at the 3-OH, 4-OH and 6-OH positions of the glucose moiety at M1 were synthesized via the reaction of M1 with acyl chloride, or acid-N,N'-diisopropylcarbodiimide in the presence of DMAP. Their structures were fully characterized by spectral methods. The cytotoxicity of these compounds against then MGC80-3 human gastric cancer cell line was also assessed. High inhibitory effects were found at a concentration of 100 μg/mL.
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spelling pubmed-62704632018-12-14 Synthesis of Esters of Ginsenoside Metabolite M1 and Their Cytotoxicity on MGC80-3 Cells Li, Wen-Fang Chen, Li-Rong Gong, Xiao-Jie Li, Zheng-Ning Li, Ke-Ke Molecules Article Monoesters of ginsenoside metabolite M1 at the 3-OH, 4-OH and 6-OH positions of the glucose moiety at M1 were synthesized via the reaction of M1 with acyl chloride, or acid-N,N'-diisopropylcarbodiimide in the presence of DMAP. Their structures were fully characterized by spectral methods. The cytotoxicity of these compounds against then MGC80-3 human gastric cancer cell line was also assessed. High inhibitory effects were found at a concentration of 100 μg/mL. MDPI 2013-03-25 /pmc/articles/PMC6270463/ /pubmed/23529029 http://dx.doi.org/10.3390/molecules18043689 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Li, Wen-Fang
Chen, Li-Rong
Gong, Xiao-Jie
Li, Zheng-Ning
Li, Ke-Ke
Synthesis of Esters of Ginsenoside Metabolite M1 and Their Cytotoxicity on MGC80-3 Cells
title Synthesis of Esters of Ginsenoside Metabolite M1 and Their Cytotoxicity on MGC80-3 Cells
title_full Synthesis of Esters of Ginsenoside Metabolite M1 and Their Cytotoxicity on MGC80-3 Cells
title_fullStr Synthesis of Esters of Ginsenoside Metabolite M1 and Their Cytotoxicity on MGC80-3 Cells
title_full_unstemmed Synthesis of Esters of Ginsenoside Metabolite M1 and Their Cytotoxicity on MGC80-3 Cells
title_short Synthesis of Esters of Ginsenoside Metabolite M1 and Their Cytotoxicity on MGC80-3 Cells
title_sort synthesis of esters of ginsenoside metabolite m1 and their cytotoxicity on mgc80-3 cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270463/
https://www.ncbi.nlm.nih.gov/pubmed/23529029
http://dx.doi.org/10.3390/molecules18043689
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AT lizhengning synthesisofestersofginsenosidemetabolitem1andtheircytotoxicityonmgc803cells
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