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Vasodilator Compounds Derived from Plants and Their Mechanisms of Action

The present paper reviews vasodilator compounds isolated from plants that were reported in the past 22 years (1990 to 2012) and the different mechanisms of action involved in their vasodilator effects. The search for reports was conducted in a comprehensive manner, intending to encompass those metab...

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Detalles Bibliográficos
Autores principales: Luna-Vázquez, Francisco J., Ibarra-Alvarado, César, Rojas-Molina, Alejandra, Rojas-Molina, Isela, Zavala-Sánchez, Miguel Ángel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270466/
https://www.ncbi.nlm.nih.gov/pubmed/23685938
http://dx.doi.org/10.3390/molecules18055814
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author Luna-Vázquez, Francisco J.
Ibarra-Alvarado, César
Rojas-Molina, Alejandra
Rojas-Molina, Isela
Zavala-Sánchez, Miguel Ángel
author_facet Luna-Vázquez, Francisco J.
Ibarra-Alvarado, César
Rojas-Molina, Alejandra
Rojas-Molina, Isela
Zavala-Sánchez, Miguel Ángel
author_sort Luna-Vázquez, Francisco J.
collection PubMed
description The present paper reviews vasodilator compounds isolated from plants that were reported in the past 22 years (1990 to 2012) and the different mechanisms of action involved in their vasodilator effects. The search for reports was conducted in a comprehensive manner, intending to encompass those metabolites with a vasodilator effect whose mechanism of action involved both vascular endothelium and arterial smooth muscle. The results obtained from our bibliographic search showed that over half of the isolated compounds have a mechanism of action involving the endothelium. Most of these bioactive metabolites cause vasodilation either by activating the nitric oxide/cGMP pathway or by blocking voltage-dependent calcium channels. Moreover, it was found that many compounds induced vasodilation by more than one mechanism. This review confirms that secondary metabolites, which include a significant group of compounds with extensive chemical diversity, are a valuable source of new pharmaceuticals useful for the treatment and prevention of cardiovascular diseases.
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spelling pubmed-62704662018-12-14 Vasodilator Compounds Derived from Plants and Their Mechanisms of Action Luna-Vázquez, Francisco J. Ibarra-Alvarado, César Rojas-Molina, Alejandra Rojas-Molina, Isela Zavala-Sánchez, Miguel Ángel Molecules Review The present paper reviews vasodilator compounds isolated from plants that were reported in the past 22 years (1990 to 2012) and the different mechanisms of action involved in their vasodilator effects. The search for reports was conducted in a comprehensive manner, intending to encompass those metabolites with a vasodilator effect whose mechanism of action involved both vascular endothelium and arterial smooth muscle. The results obtained from our bibliographic search showed that over half of the isolated compounds have a mechanism of action involving the endothelium. Most of these bioactive metabolites cause vasodilation either by activating the nitric oxide/cGMP pathway or by blocking voltage-dependent calcium channels. Moreover, it was found that many compounds induced vasodilation by more than one mechanism. This review confirms that secondary metabolites, which include a significant group of compounds with extensive chemical diversity, are a valuable source of new pharmaceuticals useful for the treatment and prevention of cardiovascular diseases. MDPI 2013-05-17 /pmc/articles/PMC6270466/ /pubmed/23685938 http://dx.doi.org/10.3390/molecules18055814 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Luna-Vázquez, Francisco J.
Ibarra-Alvarado, César
Rojas-Molina, Alejandra
Rojas-Molina, Isela
Zavala-Sánchez, Miguel Ángel
Vasodilator Compounds Derived from Plants and Their Mechanisms of Action
title Vasodilator Compounds Derived from Plants and Their Mechanisms of Action
title_full Vasodilator Compounds Derived from Plants and Their Mechanisms of Action
title_fullStr Vasodilator Compounds Derived from Plants and Their Mechanisms of Action
title_full_unstemmed Vasodilator Compounds Derived from Plants and Their Mechanisms of Action
title_short Vasodilator Compounds Derived from Plants and Their Mechanisms of Action
title_sort vasodilator compounds derived from plants and their mechanisms of action
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270466/
https://www.ncbi.nlm.nih.gov/pubmed/23685938
http://dx.doi.org/10.3390/molecules18055814
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