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Structural Correlation of Some Heterocyclic Chalcone Analogues and Evaluation of Their Antioxidant Potential
A series of six novel heterocyclic chalcone analogues 4(a–f) has been synthesized by condensing 2-acetyl-5-chlorothiophene with benzaldehyde derivatives in methanol at room temperature using a catalytic amount of sodium hydroxide. The newly synthesized compounds are characterized by IR, mass spectra...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270477/ https://www.ncbi.nlm.nih.gov/pubmed/24077177 http://dx.doi.org/10.3390/molecules181011996 |
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author | Kumar, C. S. Chidan Loh, Wan-Sin Ooi, Chin Wei Quah, Ching Kheng Fun, Hoong-Kun |
author_facet | Kumar, C. S. Chidan Loh, Wan-Sin Ooi, Chin Wei Quah, Ching Kheng Fun, Hoong-Kun |
author_sort | Kumar, C. S. Chidan |
collection | PubMed |
description | A series of six novel heterocyclic chalcone analogues 4(a–f) has been synthesized by condensing 2-acetyl-5-chlorothiophene with benzaldehyde derivatives in methanol at room temperature using a catalytic amount of sodium hydroxide. The newly synthesized compounds are characterized by IR, mass spectra, elemental analysis and melting point. Subsequently; the structures of these compounds were determined using single crystal X-ray diffraction. All the synthesized compounds were screened for their antioxidant potential by employing various in vitro models such as DPPH free radical scavenging assay, ABTS radical scavenging assay, ferric reducing antioxidant power and cupric ion reducing antioxidant capacity. Results reflect the structural impact on the antioxidant ability of the compounds. The IC(50) values illustrate the mild to good antioxidant activities of the reported compounds. Among them, 4f with a p-methoxy substituent was found to be more potent as antioxidant agent. |
format | Online Article Text |
id | pubmed-6270477 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62704772018-12-18 Structural Correlation of Some Heterocyclic Chalcone Analogues and Evaluation of Their Antioxidant Potential Kumar, C. S. Chidan Loh, Wan-Sin Ooi, Chin Wei Quah, Ching Kheng Fun, Hoong-Kun Molecules Article A series of six novel heterocyclic chalcone analogues 4(a–f) has been synthesized by condensing 2-acetyl-5-chlorothiophene with benzaldehyde derivatives in methanol at room temperature using a catalytic amount of sodium hydroxide. The newly synthesized compounds are characterized by IR, mass spectra, elemental analysis and melting point. Subsequently; the structures of these compounds were determined using single crystal X-ray diffraction. All the synthesized compounds were screened for their antioxidant potential by employing various in vitro models such as DPPH free radical scavenging assay, ABTS radical scavenging assay, ferric reducing antioxidant power and cupric ion reducing antioxidant capacity. Results reflect the structural impact on the antioxidant ability of the compounds. The IC(50) values illustrate the mild to good antioxidant activities of the reported compounds. Among them, 4f with a p-methoxy substituent was found to be more potent as antioxidant agent. MDPI 2013-09-26 /pmc/articles/PMC6270477/ /pubmed/24077177 http://dx.doi.org/10.3390/molecules181011996 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Kumar, C. S. Chidan Loh, Wan-Sin Ooi, Chin Wei Quah, Ching Kheng Fun, Hoong-Kun Structural Correlation of Some Heterocyclic Chalcone Analogues and Evaluation of Their Antioxidant Potential |
title | Structural Correlation of Some Heterocyclic Chalcone Analogues and Evaluation of Their Antioxidant Potential |
title_full | Structural Correlation of Some Heterocyclic Chalcone Analogues and Evaluation of Their Antioxidant Potential |
title_fullStr | Structural Correlation of Some Heterocyclic Chalcone Analogues and Evaluation of Their Antioxidant Potential |
title_full_unstemmed | Structural Correlation of Some Heterocyclic Chalcone Analogues and Evaluation of Their Antioxidant Potential |
title_short | Structural Correlation of Some Heterocyclic Chalcone Analogues and Evaluation of Their Antioxidant Potential |
title_sort | structural correlation of some heterocyclic chalcone analogues and evaluation of their antioxidant potential |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270477/ https://www.ncbi.nlm.nih.gov/pubmed/24077177 http://dx.doi.org/10.3390/molecules181011996 |
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