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Palladium and Organocatalysis: An Excellent Recipe for Asymmetric Synthesis

The dual activation of simple substrates by the combination of organocatalysis and palladium catalysis has been successfully applied in a variety of different asymmetric transformations. Thus, the asymmetric α-allylation of carbonyl compounds, α-fluorination of acyl derivatives, decarboxylative prot...

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Autores principales: Fernández-Ibañez, M. Ángeles, Maciá, Beatriz, Alonso, Diego A., Pastor, Isidro M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270479/
https://www.ncbi.nlm.nih.gov/pubmed/23973988
http://dx.doi.org/10.3390/molecules180910108
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author Fernández-Ibañez, M. Ángeles
Maciá, Beatriz
Alonso, Diego A.
Pastor, Isidro M.
author_facet Fernández-Ibañez, M. Ángeles
Maciá, Beatriz
Alonso, Diego A.
Pastor, Isidro M.
author_sort Fernández-Ibañez, M. Ángeles
collection PubMed
description The dual activation of simple substrates by the combination of organocatalysis and palladium catalysis has been successfully applied in a variety of different asymmetric transformations. Thus, the asymmetric α-allylation of carbonyl compounds, α-fluorination of acyl derivatives, decarboxylative protonation of β-dicarbonyl compounds, cyclization reactions of alkynyl carbonyl compounds and β-functionalization of aldehydes have been efficiently achieved employing this double-catalytic methodology.
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spelling pubmed-62704792018-12-18 Palladium and Organocatalysis: An Excellent Recipe for Asymmetric Synthesis Fernández-Ibañez, M. Ángeles Maciá, Beatriz Alonso, Diego A. Pastor, Isidro M. Molecules Review The dual activation of simple substrates by the combination of organocatalysis and palladium catalysis has been successfully applied in a variety of different asymmetric transformations. Thus, the asymmetric α-allylation of carbonyl compounds, α-fluorination of acyl derivatives, decarboxylative protonation of β-dicarbonyl compounds, cyclization reactions of alkynyl carbonyl compounds and β-functionalization of aldehydes have been efficiently achieved employing this double-catalytic methodology. MDPI 2013-08-22 /pmc/articles/PMC6270479/ /pubmed/23973988 http://dx.doi.org/10.3390/molecules180910108 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Fernández-Ibañez, M. Ángeles
Maciá, Beatriz
Alonso, Diego A.
Pastor, Isidro M.
Palladium and Organocatalysis: An Excellent Recipe for Asymmetric Synthesis
title Palladium and Organocatalysis: An Excellent Recipe for Asymmetric Synthesis
title_full Palladium and Organocatalysis: An Excellent Recipe for Asymmetric Synthesis
title_fullStr Palladium and Organocatalysis: An Excellent Recipe for Asymmetric Synthesis
title_full_unstemmed Palladium and Organocatalysis: An Excellent Recipe for Asymmetric Synthesis
title_short Palladium and Organocatalysis: An Excellent Recipe for Asymmetric Synthesis
title_sort palladium and organocatalysis: an excellent recipe for asymmetric synthesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270479/
https://www.ncbi.nlm.nih.gov/pubmed/23973988
http://dx.doi.org/10.3390/molecules180910108
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