An Efficient Synthesis of Aldohexose-Derived Piperidine Nitrones: Precursors of Piperidine Iminosugars

d-Glucopyranose-derived and l-idopyranose-derived piperidine nitrones were synthesized in good overall yields through six-step reaction sequence starting from readily available 2,3,4,6-tetra-O-benzyl-d-glucopyranose. The method is efficient and could be general for the synthesis of aldohexose-derive...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhao, Hui, Zhao, Wen-Bo, Zhu, Jian-She, Jia, Yue-Mei, Yu, Chu-Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270483/
https://www.ncbi.nlm.nih.gov/pubmed/23698053
http://dx.doi.org/10.3390/molecules18056021
_version_ 1783376709448368128
author Zhao, Hui
Zhao, Wen-Bo
Zhu, Jian-She
Jia, Yue-Mei
Yu, Chu-Yi
author_facet Zhao, Hui
Zhao, Wen-Bo
Zhu, Jian-She
Jia, Yue-Mei
Yu, Chu-Yi
author_sort Zhao, Hui
collection PubMed
description d-Glucopyranose-derived and l-idopyranose-derived piperidine nitrones were synthesized in good overall yields through six-step reaction sequence starting from readily available 2,3,4,6-tetra-O-benzyl-d-glucopyranose. The method is efficient and could be general for the synthesis of aldohexose-derived piperidine nitrones which are precursors of piperidine iminosugars.
format Online
Article
Text
id pubmed-6270483
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-62704832018-12-14 An Efficient Synthesis of Aldohexose-Derived Piperidine Nitrones: Precursors of Piperidine Iminosugars Zhao, Hui Zhao, Wen-Bo Zhu, Jian-She Jia, Yue-Mei Yu, Chu-Yi Molecules Article d-Glucopyranose-derived and l-idopyranose-derived piperidine nitrones were synthesized in good overall yields through six-step reaction sequence starting from readily available 2,3,4,6-tetra-O-benzyl-d-glucopyranose. The method is efficient and could be general for the synthesis of aldohexose-derived piperidine nitrones which are precursors of piperidine iminosugars. MDPI 2013-05-21 /pmc/articles/PMC6270483/ /pubmed/23698053 http://dx.doi.org/10.3390/molecules18056021 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Zhao, Hui
Zhao, Wen-Bo
Zhu, Jian-She
Jia, Yue-Mei
Yu, Chu-Yi
An Efficient Synthesis of Aldohexose-Derived Piperidine Nitrones: Precursors of Piperidine Iminosugars
title An Efficient Synthesis of Aldohexose-Derived Piperidine Nitrones: Precursors of Piperidine Iminosugars
title_full An Efficient Synthesis of Aldohexose-Derived Piperidine Nitrones: Precursors of Piperidine Iminosugars
title_fullStr An Efficient Synthesis of Aldohexose-Derived Piperidine Nitrones: Precursors of Piperidine Iminosugars
title_full_unstemmed An Efficient Synthesis of Aldohexose-Derived Piperidine Nitrones: Precursors of Piperidine Iminosugars
title_short An Efficient Synthesis of Aldohexose-Derived Piperidine Nitrones: Precursors of Piperidine Iminosugars
title_sort efficient synthesis of aldohexose-derived piperidine nitrones: precursors of piperidine iminosugars
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270483/
https://www.ncbi.nlm.nih.gov/pubmed/23698053
http://dx.doi.org/10.3390/molecules18056021
work_keys_str_mv AT zhaohui anefficientsynthesisofaldohexosederivedpiperidinenitronesprecursorsofpiperidineiminosugars
AT zhaowenbo anefficientsynthesisofaldohexosederivedpiperidinenitronesprecursorsofpiperidineiminosugars
AT zhujianshe anefficientsynthesisofaldohexosederivedpiperidinenitronesprecursorsofpiperidineiminosugars
AT jiayuemei anefficientsynthesisofaldohexosederivedpiperidinenitronesprecursorsofpiperidineiminosugars
AT yuchuyi anefficientsynthesisofaldohexosederivedpiperidinenitronesprecursorsofpiperidineiminosugars
AT zhaohui efficientsynthesisofaldohexosederivedpiperidinenitronesprecursorsofpiperidineiminosugars
AT zhaowenbo efficientsynthesisofaldohexosederivedpiperidinenitronesprecursorsofpiperidineiminosugars
AT zhujianshe efficientsynthesisofaldohexosederivedpiperidinenitronesprecursorsofpiperidineiminosugars
AT jiayuemei efficientsynthesisofaldohexosederivedpiperidinenitronesprecursorsofpiperidineiminosugars
AT yuchuyi efficientsynthesisofaldohexosederivedpiperidinenitronesprecursorsofpiperidineiminosugars

Ejemplares similares