Mechanistic Studies on Regioselective Dephosphorylation of Phosphate Prodrugs during a Facile Synthesis of Antitumor Phosphorylated 2-Phenyl-6,7-methylenedioxy-1H-quinolin-4-one

Phosphorylation of 2-(3-hydroxy-5-methoxyphenyl)-6,7-methylenedioxy-1H-quinolin-4-one (1) afforded diphosphate 2. We found that, upon treatment with methanol under mild conditions, 2 can undergo facile and highly regioselective dephosphorylation to give the monophosphate 3, with a phosphate group re...

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Detalles Bibliográficos
Autores principales: Cheng, Yung-Yi, Liu, Chin-Yu, Huang, Li-Jiau, Huang, Chi-Hung, Lee, Kuo-Hsiung, Lin, Cheng-Tung, Kuo, Sheng-Chu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270573/
https://www.ncbi.nlm.nih.gov/pubmed/23884134
http://dx.doi.org/10.3390/molecules18078028

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270573/
https://www.ncbi.nlm.nih.gov/pubmed/23884134
http://dx.doi.org/10.3390/molecules18078028

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