Synthesis, Spectroscopic and Semiempirical Studies of New Quaternary Alkylammonium Conjugates of Sterols

New quaternary alkylammonium conjugates of steroids were obtained by two step reaction of sterols (ergosterol, cholesterol, dihydrocholesterol) with bromoacetic acid bromide, followed by bimolecular nucleophilic substitution with a long chain tertiary alkylamine. The structures of products were conf...

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Autores principales: Brycki, Bogumił, Koenig, Hanna, Kowalczyk, Iwona, Pospieszny, Tomasz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270585/
https://www.ncbi.nlm.nih.gov/pubmed/24317524
http://dx.doi.org/10.3390/molecules181214961
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author Brycki, Bogumił
Koenig, Hanna
Kowalczyk, Iwona
Pospieszny, Tomasz
author_facet Brycki, Bogumił
Koenig, Hanna
Kowalczyk, Iwona
Pospieszny, Tomasz
author_sort Brycki, Bogumił
collection PubMed
description New quaternary alkylammonium conjugates of steroids were obtained by two step reaction of sterols (ergosterol, cholesterol, dihydrocholesterol) with bromoacetic acid bromide, followed by bimolecular nucleophilic substitution with a long chain tertiary alkylamine. The structures of products were confirmed by spectral ((1)H-NMR, (13)C-NMR, and FT-IR) analysis, mass spectrometry and PM5 semiempirical methods. The pharmacotherapeutic potential of synthesized compounds has been estimated on the basis of Prediction of Activity Spectra for Substances (PASS).
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spelling pubmed-62705852018-12-20 Synthesis, Spectroscopic and Semiempirical Studies of New Quaternary Alkylammonium Conjugates of Sterols Brycki, Bogumił Koenig, Hanna Kowalczyk, Iwona Pospieszny, Tomasz Molecules Article New quaternary alkylammonium conjugates of steroids were obtained by two step reaction of sterols (ergosterol, cholesterol, dihydrocholesterol) with bromoacetic acid bromide, followed by bimolecular nucleophilic substitution with a long chain tertiary alkylamine. The structures of products were confirmed by spectral ((1)H-NMR, (13)C-NMR, and FT-IR) analysis, mass spectrometry and PM5 semiempirical methods. The pharmacotherapeutic potential of synthesized compounds has been estimated on the basis of Prediction of Activity Spectra for Substances (PASS). MDPI 2013-12-05 /pmc/articles/PMC6270585/ /pubmed/24317524 http://dx.doi.org/10.3390/molecules181214961 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Brycki, Bogumił
Koenig, Hanna
Kowalczyk, Iwona
Pospieszny, Tomasz
Synthesis, Spectroscopic and Semiempirical Studies of New Quaternary Alkylammonium Conjugates of Sterols
title Synthesis, Spectroscopic and Semiempirical Studies of New Quaternary Alkylammonium Conjugates of Sterols
title_full Synthesis, Spectroscopic and Semiempirical Studies of New Quaternary Alkylammonium Conjugates of Sterols
title_fullStr Synthesis, Spectroscopic and Semiempirical Studies of New Quaternary Alkylammonium Conjugates of Sterols
title_full_unstemmed Synthesis, Spectroscopic and Semiempirical Studies of New Quaternary Alkylammonium Conjugates of Sterols
title_short Synthesis, Spectroscopic and Semiempirical Studies of New Quaternary Alkylammonium Conjugates of Sterols
title_sort synthesis, spectroscopic and semiempirical studies of new quaternary alkylammonium conjugates of sterols
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270585/
https://www.ncbi.nlm.nih.gov/pubmed/24317524
http://dx.doi.org/10.3390/molecules181214961
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