The Synthesis and Evaluation of Novel Hydroxyl Substituted Chalcone Analogs with in Vitro Anti-Free Radicals Pharmacological Activity and in Vivo Anti-Oxidation Activity in a Free Radical-Injury Alzheimer’s Model

Alzheimer’s disease (AD) pathogenesis involves an imbalance between free radical formation and destruction. In order to obtain a novel preclinical anti-AD drug candidate, we synthesized a series of novel hydroxyl chalcone analogs which possessed anti-free radical activity, and screened their effects...

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Detalles Bibliográficos
Autores principales: Pan, Ying, Chen, Yicun, Li, Qingnan, Yu, Xiaoyu, Wang, Jinzhi, Zheng, Jinhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270587/
https://www.ncbi.nlm.nih.gov/pubmed/23358326
http://dx.doi.org/10.3390/molecules18021693

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