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Fibrous Polymeric Composites Based on Alginate Fibres and Fibres Made of Poly-ε-caprolactone and Dibutyryl Chitin for Use in Regenerative Medicine

This work concerns the production of fibrous composite materials based on biodegradable polymers such as alginate, dibutyryl chitin (DBC) and poly-ε-caprolactone (PCL). For the production of fibres from these polymers, various spinning methods were used in order to obtain composite materials of diff...

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Detalles Bibliográficos
Autores principales: Boguń, Maciej, Krucińska, Izabella, Kommisarczyk, Agnieszka, Mikołajczyk, Teresa, Błażewicz, Marta, Stodolak-Zych, Ewa, Menaszek, Elżbieta, Ścisłowska-Czarnecka, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270599/
https://www.ncbi.nlm.nih.gov/pubmed/23528995
http://dx.doi.org/10.3390/molecules18033118
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author Boguń, Maciej
Krucińska, Izabella
Kommisarczyk, Agnieszka
Mikołajczyk, Teresa
Błażewicz, Marta
Stodolak-Zych, Ewa
Menaszek, Elżbieta
Ścisłowska-Czarnecka, Anna
author_facet Boguń, Maciej
Krucińska, Izabella
Kommisarczyk, Agnieszka
Mikołajczyk, Teresa
Błażewicz, Marta
Stodolak-Zych, Ewa
Menaszek, Elżbieta
Ścisłowska-Czarnecka, Anna
author_sort Boguń, Maciej
collection PubMed
description This work concerns the production of fibrous composite materials based on biodegradable polymers such as alginate, dibutyryl chitin (DBC) and poly-ε-caprolactone (PCL). For the production of fibres from these polymers, various spinning methods were used in order to obtain composite materials of different composition and structure. In the case of alginate fibres containing the nanoadditive tricalcium phosphate (TCP), the traditional method of forming fibres wet from solution was used. However in the case of the other two polymers the electrospinning method was used. Two model systems were tested for biocompatibility. The physicochemical and basic biological tests carried out show that the submicron fibres produced using PCL and DBC have good biocompatibility. The proposed hybrid systems composed of micrometric fibres (zinc and calcium alginates containing TCP) and submicron fibres (DBC and PCL) meet the requirements of regenerative medicine. The biomimetic fibre system, the presence of TCP nanoadditive, and the use of polymers with different resorption times provide a framework with specific properties on which bone cells are able to settle and proliferate.
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spelling pubmed-62705992018-12-20 Fibrous Polymeric Composites Based on Alginate Fibres and Fibres Made of Poly-ε-caprolactone and Dibutyryl Chitin for Use in Regenerative Medicine Boguń, Maciej Krucińska, Izabella Kommisarczyk, Agnieszka Mikołajczyk, Teresa Błażewicz, Marta Stodolak-Zych, Ewa Menaszek, Elżbieta Ścisłowska-Czarnecka, Anna Molecules Article This work concerns the production of fibrous composite materials based on biodegradable polymers such as alginate, dibutyryl chitin (DBC) and poly-ε-caprolactone (PCL). For the production of fibres from these polymers, various spinning methods were used in order to obtain composite materials of different composition and structure. In the case of alginate fibres containing the nanoadditive tricalcium phosphate (TCP), the traditional method of forming fibres wet from solution was used. However in the case of the other two polymers the electrospinning method was used. Two model systems were tested for biocompatibility. The physicochemical and basic biological tests carried out show that the submicron fibres produced using PCL and DBC have good biocompatibility. The proposed hybrid systems composed of micrometric fibres (zinc and calcium alginates containing TCP) and submicron fibres (DBC and PCL) meet the requirements of regenerative medicine. The biomimetic fibre system, the presence of TCP nanoadditive, and the use of polymers with different resorption times provide a framework with specific properties on which bone cells are able to settle and proliferate. MDPI 2013-03-08 /pmc/articles/PMC6270599/ /pubmed/23528995 http://dx.doi.org/10.3390/molecules18033118 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Boguń, Maciej
Krucińska, Izabella
Kommisarczyk, Agnieszka
Mikołajczyk, Teresa
Błażewicz, Marta
Stodolak-Zych, Ewa
Menaszek, Elżbieta
Ścisłowska-Czarnecka, Anna
Fibrous Polymeric Composites Based on Alginate Fibres and Fibres Made of Poly-ε-caprolactone and Dibutyryl Chitin for Use in Regenerative Medicine
title Fibrous Polymeric Composites Based on Alginate Fibres and Fibres Made of Poly-ε-caprolactone and Dibutyryl Chitin for Use in Regenerative Medicine
title_full Fibrous Polymeric Composites Based on Alginate Fibres and Fibres Made of Poly-ε-caprolactone and Dibutyryl Chitin for Use in Regenerative Medicine
title_fullStr Fibrous Polymeric Composites Based on Alginate Fibres and Fibres Made of Poly-ε-caprolactone and Dibutyryl Chitin for Use in Regenerative Medicine
title_full_unstemmed Fibrous Polymeric Composites Based on Alginate Fibres and Fibres Made of Poly-ε-caprolactone and Dibutyryl Chitin for Use in Regenerative Medicine
title_short Fibrous Polymeric Composites Based on Alginate Fibres and Fibres Made of Poly-ε-caprolactone and Dibutyryl Chitin for Use in Regenerative Medicine
title_sort fibrous polymeric composites based on alginate fibres and fibres made of poly-ε-caprolactone and dibutyryl chitin for use in regenerative medicine
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270599/
https://www.ncbi.nlm.nih.gov/pubmed/23528995
http://dx.doi.org/10.3390/molecules18033118
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