Cytotoxicity and Anti-Inflammatory Activity of Methylsulfanyl-triazoloquinazolines

A series of twenty five 2-methylsulfanyl-[1,2,4]triazolo[1,5-a]quinazoline derivatives 1–25 was previously synthesized. We have now investigated their cytotoxic effects against hepatocellular Hep-G2 and colon HCT-116 carcinoma cells and effect on the macrophage growth, in addition to their influence...

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Autores principales: Al-Salahi, Rashad A., Gamal-Eldeen, Amira M., Alanazi, Amer M., Al-Omar, Mohamed A., Marzouk, Mohamed A., Fouda, Moustafa M. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270609/
https://www.ncbi.nlm.nih.gov/pubmed/23348996
http://dx.doi.org/10.3390/molecules18021434
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author Al-Salahi, Rashad A.
Gamal-Eldeen, Amira M.
Alanazi, Amer M.
Al-Omar, Mohamed A.
Marzouk, Mohamed A.
Fouda, Moustafa M. G.
author_facet Al-Salahi, Rashad A.
Gamal-Eldeen, Amira M.
Alanazi, Amer M.
Al-Omar, Mohamed A.
Marzouk, Mohamed A.
Fouda, Moustafa M. G.
author_sort Al-Salahi, Rashad A.
collection PubMed
description A series of twenty five 2-methylsulfanyl-[1,2,4]triazolo[1,5-a]quinazoline derivatives 1–25 was previously synthesized. We have now investigated their cytotoxic effects against hepatocellular Hep-G2 and colon HCT-116 carcinoma cells and effect on the macrophage growth, in addition to their influence of the inflammatory mediators [nitric oxide (NO), tumor necrosis factor-α (TNF-α), prostaglandin E-2 (PGE-2) and in bacterial lipopolysachharide (LPS)-stimulated macrophages]. The findings revealed that compounds 13 and 17 showed the highest cytotoxicity and that 3, 6–8 and 25 are promising multi-potent anti-inflammatory agents.
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spelling pubmed-62706092018-12-14 Cytotoxicity and Anti-Inflammatory Activity of Methylsulfanyl-triazoloquinazolines Al-Salahi, Rashad A. Gamal-Eldeen, Amira M. Alanazi, Amer M. Al-Omar, Mohamed A. Marzouk, Mohamed A. Fouda, Moustafa M. G. Molecules Article A series of twenty five 2-methylsulfanyl-[1,2,4]triazolo[1,5-a]quinazoline derivatives 1–25 was previously synthesized. We have now investigated their cytotoxic effects against hepatocellular Hep-G2 and colon HCT-116 carcinoma cells and effect on the macrophage growth, in addition to their influence of the inflammatory mediators [nitric oxide (NO), tumor necrosis factor-α (TNF-α), prostaglandin E-2 (PGE-2) and in bacterial lipopolysachharide (LPS)-stimulated macrophages]. The findings revealed that compounds 13 and 17 showed the highest cytotoxicity and that 3, 6–8 and 25 are promising multi-potent anti-inflammatory agents. MDPI 2013-01-24 /pmc/articles/PMC6270609/ /pubmed/23348996 http://dx.doi.org/10.3390/molecules18021434 Text en © 2013 by the author. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Al-Salahi, Rashad A.
Gamal-Eldeen, Amira M.
Alanazi, Amer M.
Al-Omar, Mohamed A.
Marzouk, Mohamed A.
Fouda, Moustafa M. G.
Cytotoxicity and Anti-Inflammatory Activity of Methylsulfanyl-triazoloquinazolines
title Cytotoxicity and Anti-Inflammatory Activity of Methylsulfanyl-triazoloquinazolines
title_full Cytotoxicity and Anti-Inflammatory Activity of Methylsulfanyl-triazoloquinazolines
title_fullStr Cytotoxicity and Anti-Inflammatory Activity of Methylsulfanyl-triazoloquinazolines
title_full_unstemmed Cytotoxicity and Anti-Inflammatory Activity of Methylsulfanyl-triazoloquinazolines
title_short Cytotoxicity and Anti-Inflammatory Activity of Methylsulfanyl-triazoloquinazolines
title_sort cytotoxicity and anti-inflammatory activity of methylsulfanyl-triazoloquinazolines
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270609/
https://www.ncbi.nlm.nih.gov/pubmed/23348996
http://dx.doi.org/10.3390/molecules18021434
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