Synthesis of Tricyclic Condensed Rings Incorporating the Pyrazole or Isoxazole Moieties Bonded to a 4-Piperidinyl Substituent

In this paper we report the synthesis of new compounds based on the pyrazole and isoxazole framework fused to a cycloalkene unit, and bearing as a substituent the 1-piperidinyl group as new examples of potential antipsychotic molecules. The general synthesis involves the acylation of a chloro-substi...

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Detalles Bibliográficos
Autores principales: Pinna, Giansalvo, Loriga, Giovanni, Pinna, Gérard A., Chelucci, Giorgio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270620/
https://www.ncbi.nlm.nih.gov/pubmed/23846755
http://dx.doi.org/10.3390/molecules18078147
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author Pinna, Giansalvo
Loriga, Giovanni
Pinna, Gérard A.
Chelucci, Giorgio
author_facet Pinna, Giansalvo
Loriga, Giovanni
Pinna, Gérard A.
Chelucci, Giorgio
author_sort Pinna, Giansalvo
collection PubMed
description In this paper we report the synthesis of new compounds based on the pyrazole and isoxazole framework fused to a cycloalkene unit, and bearing as a substituent the 1-piperidinyl group as new examples of potential antipsychotic molecules. The general synthesis involves the acylation of a chloro-substituted cyclic ketone with a 1-substituted piperidine-4-carboxylate derivative, followed by heterocyclization of the formed 1,3-dioxo compound with a hydrazine or hydroxylamine.
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spelling pubmed-62706202018-12-17 Synthesis of Tricyclic Condensed Rings Incorporating the Pyrazole or Isoxazole Moieties Bonded to a 4-Piperidinyl Substituent Pinna, Giansalvo Loriga, Giovanni Pinna, Gérard A. Chelucci, Giorgio Molecules Article In this paper we report the synthesis of new compounds based on the pyrazole and isoxazole framework fused to a cycloalkene unit, and bearing as a substituent the 1-piperidinyl group as new examples of potential antipsychotic molecules. The general synthesis involves the acylation of a chloro-substituted cyclic ketone with a 1-substituted piperidine-4-carboxylate derivative, followed by heterocyclization of the formed 1,3-dioxo compound with a hydrazine or hydroxylamine. MDPI 2013-07-10 /pmc/articles/PMC6270620/ /pubmed/23846755 http://dx.doi.org/10.3390/molecules18078147 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Pinna, Giansalvo
Loriga, Giovanni
Pinna, Gérard A.
Chelucci, Giorgio
Synthesis of Tricyclic Condensed Rings Incorporating the Pyrazole or Isoxazole Moieties Bonded to a 4-Piperidinyl Substituent
title Synthesis of Tricyclic Condensed Rings Incorporating the Pyrazole or Isoxazole Moieties Bonded to a 4-Piperidinyl Substituent
title_full Synthesis of Tricyclic Condensed Rings Incorporating the Pyrazole or Isoxazole Moieties Bonded to a 4-Piperidinyl Substituent
title_fullStr Synthesis of Tricyclic Condensed Rings Incorporating the Pyrazole or Isoxazole Moieties Bonded to a 4-Piperidinyl Substituent
title_full_unstemmed Synthesis of Tricyclic Condensed Rings Incorporating the Pyrazole or Isoxazole Moieties Bonded to a 4-Piperidinyl Substituent
title_short Synthesis of Tricyclic Condensed Rings Incorporating the Pyrazole or Isoxazole Moieties Bonded to a 4-Piperidinyl Substituent
title_sort synthesis of tricyclic condensed rings incorporating the pyrazole or isoxazole moieties bonded to a 4-piperidinyl substituent
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270620/
https://www.ncbi.nlm.nih.gov/pubmed/23846755
http://dx.doi.org/10.3390/molecules18078147
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