The Toxicological Assessment of Cyclopentyl Methyl Ether (CPME) as a Green Solvent

Cyclopentyl methyl ether (CPME) has been used in chemical synthesis as an alternative to hazardous solvents. According to some earlier investigation by others, CPME has low acute or subchronic toxicity with moderate irritation and negative mutagenicity and negative skin sensitization (Local Lymph No...

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Autor principal: Watanabe, Kiyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270629/
https://www.ncbi.nlm.nih.gov/pubmed/23478516
http://dx.doi.org/10.3390/molecules18033183
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author Watanabe, Kiyoshi
author_facet Watanabe, Kiyoshi
author_sort Watanabe, Kiyoshi
collection PubMed
description Cyclopentyl methyl ether (CPME) has been used in chemical synthesis as an alternative to hazardous solvents. According to some earlier investigation by others, CPME has low acute or subchronic toxicity with moderate irritation and negative mutagenicity and negative skin sensitization (Local Lymph Node Assay). Calculated Permitted Daily Exposure (PDE) value of CPME obtained by our 28-day oral toxicity test is 1.5 mg/day, and CPME is thus assumed to be a class 2 equivalent solvent in the ICH (International Conference on Harmonization) Harmonized Tripartite Guideline Q3C (R5). Wide synthetic utility and a detailed toxicity study suggest CPME as a green and sustainable solvent of choice for modern chemical transformations.
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spelling pubmed-62706292018-12-20 The Toxicological Assessment of Cyclopentyl Methyl Ether (CPME) as a Green Solvent Watanabe, Kiyoshi Molecules Communication Cyclopentyl methyl ether (CPME) has been used in chemical synthesis as an alternative to hazardous solvents. According to some earlier investigation by others, CPME has low acute or subchronic toxicity with moderate irritation and negative mutagenicity and negative skin sensitization (Local Lymph Node Assay). Calculated Permitted Daily Exposure (PDE) value of CPME obtained by our 28-day oral toxicity test is 1.5 mg/day, and CPME is thus assumed to be a class 2 equivalent solvent in the ICH (International Conference on Harmonization) Harmonized Tripartite Guideline Q3C (R5). Wide synthetic utility and a detailed toxicity study suggest CPME as a green and sustainable solvent of choice for modern chemical transformations. MDPI 2013-03-11 /pmc/articles/PMC6270629/ /pubmed/23478516 http://dx.doi.org/10.3390/molecules18033183 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Communication
Watanabe, Kiyoshi
The Toxicological Assessment of Cyclopentyl Methyl Ether (CPME) as a Green Solvent
title The Toxicological Assessment of Cyclopentyl Methyl Ether (CPME) as a Green Solvent
title_full The Toxicological Assessment of Cyclopentyl Methyl Ether (CPME) as a Green Solvent
title_fullStr The Toxicological Assessment of Cyclopentyl Methyl Ether (CPME) as a Green Solvent
title_full_unstemmed The Toxicological Assessment of Cyclopentyl Methyl Ether (CPME) as a Green Solvent
title_short The Toxicological Assessment of Cyclopentyl Methyl Ether (CPME) as a Green Solvent
title_sort toxicological assessment of cyclopentyl methyl ether (cpme) as a green solvent
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270629/
https://www.ncbi.nlm.nih.gov/pubmed/23478516
http://dx.doi.org/10.3390/molecules18033183
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