Cargando…
Assessment of the Anti-Protozoal Activity of Crude Carica papaya Seed Extract against Trypanosoma cruzi
In order to determine the in vivo activity against the protozoan Trypanosoma cruzi, two doses (50 and 75 mg/kg) of a chloroform extract of Carica papaya seeds were evaluated compared with a control group of allopurinol. The activity of a mixture of the three main compounds (oleic, palmitic and stear...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270640/ https://www.ncbi.nlm.nih.gov/pubmed/24126379 http://dx.doi.org/10.3390/molecules181012621 |
_version_ | 1783376745385164800 |
---|---|
author | Jiménez-Coello, Matilde Guzman-Marín, Eugenia Ortega-Pacheco, Antonio Perez-Gutiérrez, Salud Acosta-Viana, Karla Y. |
author_facet | Jiménez-Coello, Matilde Guzman-Marín, Eugenia Ortega-Pacheco, Antonio Perez-Gutiérrez, Salud Acosta-Viana, Karla Y. |
author_sort | Jiménez-Coello, Matilde |
collection | PubMed |
description | In order to determine the in vivo activity against the protozoan Trypanosoma cruzi, two doses (50 and 75 mg/kg) of a chloroform extract of Carica papaya seeds were evaluated compared with a control group of allopurinol. The activity of a mixture of the three main compounds (oleic, palmitic and stearic acids in a proportion of 45.9% of oleic acid, 24.1% of palmitic and 8.52% of stearic acid previously identified in the crude extract of C. papaya was evaluated at doses of 100, 200 and 300 mg/kg. Both doses of the extracts were orally administered for 28 days. A significant reduction (p < 0.05) in the number of blood trypomastigotes was observed in animals treated with the evaluated doses of the C. papaya extract in comparison with the positive control group (allopurinol 8.5 mg/kg). Parasitemia in animals treated with the fatty acids mixture was also significantly reduced (p < 0.05), compared to negative control animals. These results demonstrate that the fatty acids identified in the seed extracts of C. papaya (from ripe fruit) are able to reduce the number of parasites from both parasite stages, blood trypomastigote and amastigote (intracellular stage). |
format | Online Article Text |
id | pubmed-6270640 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62706402018-12-18 Assessment of the Anti-Protozoal Activity of Crude Carica papaya Seed Extract against Trypanosoma cruzi Jiménez-Coello, Matilde Guzman-Marín, Eugenia Ortega-Pacheco, Antonio Perez-Gutiérrez, Salud Acosta-Viana, Karla Y. Molecules Article In order to determine the in vivo activity against the protozoan Trypanosoma cruzi, two doses (50 and 75 mg/kg) of a chloroform extract of Carica papaya seeds were evaluated compared with a control group of allopurinol. The activity of a mixture of the three main compounds (oleic, palmitic and stearic acids in a proportion of 45.9% of oleic acid, 24.1% of palmitic and 8.52% of stearic acid previously identified in the crude extract of C. papaya was evaluated at doses of 100, 200 and 300 mg/kg. Both doses of the extracts were orally administered for 28 days. A significant reduction (p < 0.05) in the number of blood trypomastigotes was observed in animals treated with the evaluated doses of the C. papaya extract in comparison with the positive control group (allopurinol 8.5 mg/kg). Parasitemia in animals treated with the fatty acids mixture was also significantly reduced (p < 0.05), compared to negative control animals. These results demonstrate that the fatty acids identified in the seed extracts of C. papaya (from ripe fruit) are able to reduce the number of parasites from both parasite stages, blood trypomastigote and amastigote (intracellular stage). MDPI 2013-10-11 /pmc/articles/PMC6270640/ /pubmed/24126379 http://dx.doi.org/10.3390/molecules181012621 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Jiménez-Coello, Matilde Guzman-Marín, Eugenia Ortega-Pacheco, Antonio Perez-Gutiérrez, Salud Acosta-Viana, Karla Y. Assessment of the Anti-Protozoal Activity of Crude Carica papaya Seed Extract against Trypanosoma cruzi |
title | Assessment of the Anti-Protozoal Activity of Crude Carica papaya Seed Extract against Trypanosoma cruzi |
title_full | Assessment of the Anti-Protozoal Activity of Crude Carica papaya Seed Extract against Trypanosoma cruzi |
title_fullStr | Assessment of the Anti-Protozoal Activity of Crude Carica papaya Seed Extract against Trypanosoma cruzi |
title_full_unstemmed | Assessment of the Anti-Protozoal Activity of Crude Carica papaya Seed Extract against Trypanosoma cruzi |
title_short | Assessment of the Anti-Protozoal Activity of Crude Carica papaya Seed Extract against Trypanosoma cruzi |
title_sort | assessment of the anti-protozoal activity of crude carica papaya seed extract against trypanosoma cruzi |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270640/ https://www.ncbi.nlm.nih.gov/pubmed/24126379 http://dx.doi.org/10.3390/molecules181012621 |
work_keys_str_mv | AT jimenezcoellomatilde assessmentoftheantiprotozoalactivityofcrudecaricapapayaseedextractagainsttrypanosomacruzi AT guzmanmarineugenia assessmentoftheantiprotozoalactivityofcrudecaricapapayaseedextractagainsttrypanosomacruzi AT ortegapachecoantonio assessmentoftheantiprotozoalactivityofcrudecaricapapayaseedextractagainsttrypanosomacruzi AT perezgutierrezsalud assessmentoftheantiprotozoalactivityofcrudecaricapapayaseedextractagainsttrypanosomacruzi AT acostavianakarlay assessmentoftheantiprotozoalactivityofcrudecaricapapayaseedextractagainsttrypanosomacruzi |