Structures of Two New Flavonoids and Effects of Licorice Phenolics on Vancomycin-Resistant Enterococcus Species

Since our previous study revealed that several licorice phenolics have antibacterial effects on methicillin-resistant Staphylococcus aureus (MRSA), and suppressive effects on the oxacillin resistance of MRSA, we further investigated effectiveness of licorice constituents on vancomycin-resistant Ente...

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Autores principales: Eerdunbayaer, Orabi, Mohamed A. A., Aoyama, Hiroe, Kuroda, Teruo, Hatano, Tsutomu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270663/
https://www.ncbi.nlm.nih.gov/pubmed/24686577
http://dx.doi.org/10.3390/molecules19043883
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author Eerdunbayaer,
Orabi, Mohamed A. A.
Aoyama, Hiroe
Kuroda, Teruo
Hatano, Tsutomu
author_facet Eerdunbayaer,
Orabi, Mohamed A. A.
Aoyama, Hiroe
Kuroda, Teruo
Hatano, Tsutomu
author_sort Eerdunbayaer,
collection PubMed
description Since our previous study revealed that several licorice phenolics have antibacterial effects on methicillin-resistant Staphylococcus aureus (MRSA), and suppressive effects on the oxacillin resistance of MRSA, we further investigated effectiveness of licorice constituents on vancomycin-resistant Enterococcus (VRE) bacteria, and purified 32 phenolic compounds. Two flavonoids among them were characterized structurally, and identified their structures as demethylglycyrol (31) and 5,7-di-O-methylluteone (32), respectively. Examination of antibacterial effects of licorice phenolics showed that 3-arylcoumarins such as licoarylcoumarin (9) and glycycoumarin (26), and 2-arylcoumarones such as gancaonin I (17), have moderate to potent antibacterial effects on the VRE strains used in this study.
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spelling pubmed-62706632019-01-02 Structures of Two New Flavonoids and Effects of Licorice Phenolics on Vancomycin-Resistant Enterococcus Species Eerdunbayaer, Orabi, Mohamed A. A. Aoyama, Hiroe Kuroda, Teruo Hatano, Tsutomu Molecules Article Since our previous study revealed that several licorice phenolics have antibacterial effects on methicillin-resistant Staphylococcus aureus (MRSA), and suppressive effects on the oxacillin resistance of MRSA, we further investigated effectiveness of licorice constituents on vancomycin-resistant Enterococcus (VRE) bacteria, and purified 32 phenolic compounds. Two flavonoids among them were characterized structurally, and identified their structures as demethylglycyrol (31) and 5,7-di-O-methylluteone (32), respectively. Examination of antibacterial effects of licorice phenolics showed that 3-arylcoumarins such as licoarylcoumarin (9) and glycycoumarin (26), and 2-arylcoumarones such as gancaonin I (17), have moderate to potent antibacterial effects on the VRE strains used in this study. MDPI 2014-03-28 /pmc/articles/PMC6270663/ /pubmed/24686577 http://dx.doi.org/10.3390/molecules19043883 Text en © 2014 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Eerdunbayaer,
Orabi, Mohamed A. A.
Aoyama, Hiroe
Kuroda, Teruo
Hatano, Tsutomu
Structures of Two New Flavonoids and Effects of Licorice Phenolics on Vancomycin-Resistant Enterococcus Species
title Structures of Two New Flavonoids and Effects of Licorice Phenolics on Vancomycin-Resistant Enterococcus Species
title_full Structures of Two New Flavonoids and Effects of Licorice Phenolics on Vancomycin-Resistant Enterococcus Species
title_fullStr Structures of Two New Flavonoids and Effects of Licorice Phenolics on Vancomycin-Resistant Enterococcus Species
title_full_unstemmed Structures of Two New Flavonoids and Effects of Licorice Phenolics on Vancomycin-Resistant Enterococcus Species
title_short Structures of Two New Flavonoids and Effects of Licorice Phenolics on Vancomycin-Resistant Enterococcus Species
title_sort structures of two new flavonoids and effects of licorice phenolics on vancomycin-resistant enterococcus species
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270663/
https://www.ncbi.nlm.nih.gov/pubmed/24686577
http://dx.doi.org/10.3390/molecules19043883
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