Development of an Advanced Synthetic Route to Macrosphelides and Its Application to the Discovery of a More Potent Macrosphelide Derivative

The discovery of a more cytotoxic macrosphelide derivative, including its total synthesis and bioassay are described. Application of the Koide protocol to a readily available propagylic alcohol allowed the rapid and practical synthesis of a macrosphelide A skeleton. This strategy enabled the success...

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Detalles Bibliográficos
Autores principales: Heo, Yu Mi, Lee, Hunseok, Shin, Young Kee, Paek, Seung-Mann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270677/
https://www.ncbi.nlm.nih.gov/pubmed/25268715
http://dx.doi.org/10.3390/molecules191015572
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author Heo, Yu Mi
Lee, Hunseok
Shin, Young Kee
Paek, Seung-Mann
author_facet Heo, Yu Mi
Lee, Hunseok
Shin, Young Kee
Paek, Seung-Mann
author_sort Heo, Yu Mi
collection PubMed
description The discovery of a more cytotoxic macrosphelide derivative, including its total synthesis and bioassay are described. Application of the Koide protocol to a readily available propagylic alcohol allowed the rapid and practical synthesis of a macrosphelide A skeleton. This strategy enabled the successful improvement of the cytotoxic activity of the macrosphelide derivative.
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spelling pubmed-62706772018-12-27 Development of an Advanced Synthetic Route to Macrosphelides and Its Application to the Discovery of a More Potent Macrosphelide Derivative Heo, Yu Mi Lee, Hunseok Shin, Young Kee Paek, Seung-Mann Molecules Article The discovery of a more cytotoxic macrosphelide derivative, including its total synthesis and bioassay are described. Application of the Koide protocol to a readily available propagylic alcohol allowed the rapid and practical synthesis of a macrosphelide A skeleton. This strategy enabled the successful improvement of the cytotoxic activity of the macrosphelide derivative. MDPI 2014-09-29 /pmc/articles/PMC6270677/ /pubmed/25268715 http://dx.doi.org/10.3390/molecules191015572 Text en © 2014 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Heo, Yu Mi
Lee, Hunseok
Shin, Young Kee
Paek, Seung-Mann
Development of an Advanced Synthetic Route to Macrosphelides and Its Application to the Discovery of a More Potent Macrosphelide Derivative
title Development of an Advanced Synthetic Route to Macrosphelides and Its Application to the Discovery of a More Potent Macrosphelide Derivative
title_full Development of an Advanced Synthetic Route to Macrosphelides and Its Application to the Discovery of a More Potent Macrosphelide Derivative
title_fullStr Development of an Advanced Synthetic Route to Macrosphelides and Its Application to the Discovery of a More Potent Macrosphelide Derivative
title_full_unstemmed Development of an Advanced Synthetic Route to Macrosphelides and Its Application to the Discovery of a More Potent Macrosphelide Derivative
title_short Development of an Advanced Synthetic Route to Macrosphelides and Its Application to the Discovery of a More Potent Macrosphelide Derivative
title_sort development of an advanced synthetic route to macrosphelides and its application to the discovery of a more potent macrosphelide derivative
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270677/
https://www.ncbi.nlm.nih.gov/pubmed/25268715
http://dx.doi.org/10.3390/molecules191015572
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