Highly Efficient and Diastereoselective Synthesis of New Pyrazolylpyrrolizine and Pyrazolylpyrrolidine Derivates by a Three-Component Domino Process

Diastereoselective reactions between 4-formylpyrazoles, N-substituted maleimides and glycine derivates led to new series of pyrazolyldipyrrolo [3,4-a:3',4'-f]pyrrolizines and pyrazolylpyrrolo[3,4-c]pyrroles in good yields. The reactions proceeded by a domino process through azomethine ylid...

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Detalles Bibliográficos
Autores principales: Quiroga, Jairo, Gálvez, Jaime, Abonia, Rodrigo, Insuasty, Braulio, Ortíz, Alejandro, Cobo, Justo, Nogueras, Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270732/
https://www.ncbi.nlm.nih.gov/pubmed/24714191
http://dx.doi.org/10.3390/molecules19044284
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author Quiroga, Jairo
Gálvez, Jaime
Abonia, Rodrigo
Insuasty, Braulio
Ortíz, Alejandro
Cobo, Justo
Nogueras, Manuel
author_facet Quiroga, Jairo
Gálvez, Jaime
Abonia, Rodrigo
Insuasty, Braulio
Ortíz, Alejandro
Cobo, Justo
Nogueras, Manuel
author_sort Quiroga, Jairo
collection PubMed
description Diastereoselective reactions between 4-formylpyrazoles, N-substituted maleimides and glycine derivates led to new series of pyrazolyldipyrrolo [3,4-a:3',4'-f]pyrrolizines and pyrazolylpyrrolo[3,4-c]pyrroles in good yields. The reactions proceeded by a domino process through azomethine ylides formed in situ via a 1,3-dipolar cycloaddition reaction.
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spelling pubmed-62707322019-01-02 Highly Efficient and Diastereoselective Synthesis of New Pyrazolylpyrrolizine and Pyrazolylpyrrolidine Derivates by a Three-Component Domino Process Quiroga, Jairo Gálvez, Jaime Abonia, Rodrigo Insuasty, Braulio Ortíz, Alejandro Cobo, Justo Nogueras, Manuel Molecules Article Diastereoselective reactions between 4-formylpyrazoles, N-substituted maleimides and glycine derivates led to new series of pyrazolyldipyrrolo [3,4-a:3',4'-f]pyrrolizines and pyrazolylpyrrolo[3,4-c]pyrroles in good yields. The reactions proceeded by a domino process through azomethine ylides formed in situ via a 1,3-dipolar cycloaddition reaction. MDPI 2014-04-04 /pmc/articles/PMC6270732/ /pubmed/24714191 http://dx.doi.org/10.3390/molecules19044284 Text en © 2014 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Quiroga, Jairo
Gálvez, Jaime
Abonia, Rodrigo
Insuasty, Braulio
Ortíz, Alejandro
Cobo, Justo
Nogueras, Manuel
Highly Efficient and Diastereoselective Synthesis of New Pyrazolylpyrrolizine and Pyrazolylpyrrolidine Derivates by a Three-Component Domino Process
title Highly Efficient and Diastereoselective Synthesis of New Pyrazolylpyrrolizine and Pyrazolylpyrrolidine Derivates by a Three-Component Domino Process
title_full Highly Efficient and Diastereoselective Synthesis of New Pyrazolylpyrrolizine and Pyrazolylpyrrolidine Derivates by a Three-Component Domino Process
title_fullStr Highly Efficient and Diastereoselective Synthesis of New Pyrazolylpyrrolizine and Pyrazolylpyrrolidine Derivates by a Three-Component Domino Process
title_full_unstemmed Highly Efficient and Diastereoselective Synthesis of New Pyrazolylpyrrolizine and Pyrazolylpyrrolidine Derivates by a Three-Component Domino Process
title_short Highly Efficient and Diastereoselective Synthesis of New Pyrazolylpyrrolizine and Pyrazolylpyrrolidine Derivates by a Three-Component Domino Process
title_sort highly efficient and diastereoselective synthesis of new pyrazolylpyrrolizine and pyrazolylpyrrolidine derivates by a three-component domino process
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270732/
https://www.ncbi.nlm.nih.gov/pubmed/24714191
http://dx.doi.org/10.3390/molecules19044284
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