Discovery of Novel Small-Molecule Compounds with Selective Cytotoxicity for Burkitt’s Lymphoma Cells Using 3D Ligand-Based Virtual Screening

We describe a ligand-based approach towards compounds with more specific targeting for Burkitt’s lymphoma. Using three-dimensional ligand-based similarity searches and a previously described hit compound, we have identified six compounds that are chemically different but with similar spatial conform...

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Detalles Bibliográficos
Autores principales: Gobec, Martina, Sosič, Izidor, Brus, Boris, Obreza, Aleš, Gobec, Stanislav, Mlinarič-Raščan, Irena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270761/
https://www.ncbi.nlm.nih.gov/pubmed/25415480
http://dx.doi.org/10.3390/molecules191119209

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270761/
https://www.ncbi.nlm.nih.gov/pubmed/25415480
http://dx.doi.org/10.3390/molecules191119209

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