Cargando…

1,4-Naphthoquinones: From Oxidative Damage to Cellular and Inter-Cellular Signaling

Naphthoquinones may cause oxidative stress in exposed cells and, therefore, affect redox signaling. Here, contributions of redox cycling and alkylating properties of quinones (both natural and synthetic, such as plumbagin, juglone, lawsone, menadione, methoxy-naphthoquinones, and others) to cellular...

Descripción completa

Detalles Bibliográficos
Autores principales: Klotz, Lars-Oliver, Hou, Xiaoqing, Jacob, Claus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270801/
https://www.ncbi.nlm.nih.gov/pubmed/25232709
http://dx.doi.org/10.3390/molecules190914902
_version_ 1783376782349565952
author Klotz, Lars-Oliver
Hou, Xiaoqing
Jacob, Claus
author_facet Klotz, Lars-Oliver
Hou, Xiaoqing
Jacob, Claus
author_sort Klotz, Lars-Oliver
collection PubMed
description Naphthoquinones may cause oxidative stress in exposed cells and, therefore, affect redox signaling. Here, contributions of redox cycling and alkylating properties of quinones (both natural and synthetic, such as plumbagin, juglone, lawsone, menadione, methoxy-naphthoquinones, and others) to cellular and inter-cellular signaling processes are discussed: (i) naphthoquinone-induced Nrf2-dependent modulation of gene expression and its potentially beneficial outcome; (ii) the modulation of receptor tyrosine kinases, such as the epidermal growth factor receptor by naphthoquinones, resulting in altered gap junctional intercellular communication. Generation of reactive oxygen species and modulation of redox signaling are properties of naphthoquinones that render them interesting leads for the development of novel compounds of potential use in various therapeutic settings.
format Online
Article
Text
id pubmed-6270801
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-62708012018-12-27 1,4-Naphthoquinones: From Oxidative Damage to Cellular and Inter-Cellular Signaling Klotz, Lars-Oliver Hou, Xiaoqing Jacob, Claus Molecules Review Naphthoquinones may cause oxidative stress in exposed cells and, therefore, affect redox signaling. Here, contributions of redox cycling and alkylating properties of quinones (both natural and synthetic, such as plumbagin, juglone, lawsone, menadione, methoxy-naphthoquinones, and others) to cellular and inter-cellular signaling processes are discussed: (i) naphthoquinone-induced Nrf2-dependent modulation of gene expression and its potentially beneficial outcome; (ii) the modulation of receptor tyrosine kinases, such as the epidermal growth factor receptor by naphthoquinones, resulting in altered gap junctional intercellular communication. Generation of reactive oxygen species and modulation of redox signaling are properties of naphthoquinones that render them interesting leads for the development of novel compounds of potential use in various therapeutic settings. MDPI 2014-09-17 /pmc/articles/PMC6270801/ /pubmed/25232709 http://dx.doi.org/10.3390/molecules190914902 Text en © 2014 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Klotz, Lars-Oliver
Hou, Xiaoqing
Jacob, Claus
1,4-Naphthoquinones: From Oxidative Damage to Cellular and Inter-Cellular Signaling
title 1,4-Naphthoquinones: From Oxidative Damage to Cellular and Inter-Cellular Signaling
title_full 1,4-Naphthoquinones: From Oxidative Damage to Cellular and Inter-Cellular Signaling
title_fullStr 1,4-Naphthoquinones: From Oxidative Damage to Cellular and Inter-Cellular Signaling
title_full_unstemmed 1,4-Naphthoquinones: From Oxidative Damage to Cellular and Inter-Cellular Signaling
title_short 1,4-Naphthoquinones: From Oxidative Damage to Cellular and Inter-Cellular Signaling
title_sort 1,4-naphthoquinones: from oxidative damage to cellular and inter-cellular signaling
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270801/
https://www.ncbi.nlm.nih.gov/pubmed/25232709
http://dx.doi.org/10.3390/molecules190914902
work_keys_str_mv AT klotzlarsoliver 14naphthoquinonesfromoxidativedamagetocellularandintercellularsignaling
AT houxiaoqing 14naphthoquinonesfromoxidativedamagetocellularandintercellularsignaling
AT jacobclaus 14naphthoquinonesfromoxidativedamagetocellularandintercellularsignaling