Cargando…
1,4-Naphthoquinones: From Oxidative Damage to Cellular and Inter-Cellular Signaling
Naphthoquinones may cause oxidative stress in exposed cells and, therefore, affect redox signaling. Here, contributions of redox cycling and alkylating properties of quinones (both natural and synthetic, such as plumbagin, juglone, lawsone, menadione, methoxy-naphthoquinones, and others) to cellular...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270801/ https://www.ncbi.nlm.nih.gov/pubmed/25232709 http://dx.doi.org/10.3390/molecules190914902 |
_version_ | 1783376782349565952 |
---|---|
author | Klotz, Lars-Oliver Hou, Xiaoqing Jacob, Claus |
author_facet | Klotz, Lars-Oliver Hou, Xiaoqing Jacob, Claus |
author_sort | Klotz, Lars-Oliver |
collection | PubMed |
description | Naphthoquinones may cause oxidative stress in exposed cells and, therefore, affect redox signaling. Here, contributions of redox cycling and alkylating properties of quinones (both natural and synthetic, such as plumbagin, juglone, lawsone, menadione, methoxy-naphthoquinones, and others) to cellular and inter-cellular signaling processes are discussed: (i) naphthoquinone-induced Nrf2-dependent modulation of gene expression and its potentially beneficial outcome; (ii) the modulation of receptor tyrosine kinases, such as the epidermal growth factor receptor by naphthoquinones, resulting in altered gap junctional intercellular communication. Generation of reactive oxygen species and modulation of redox signaling are properties of naphthoquinones that render them interesting leads for the development of novel compounds of potential use in various therapeutic settings. |
format | Online Article Text |
id | pubmed-6270801 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62708012018-12-27 1,4-Naphthoquinones: From Oxidative Damage to Cellular and Inter-Cellular Signaling Klotz, Lars-Oliver Hou, Xiaoqing Jacob, Claus Molecules Review Naphthoquinones may cause oxidative stress in exposed cells and, therefore, affect redox signaling. Here, contributions of redox cycling and alkylating properties of quinones (both natural and synthetic, such as plumbagin, juglone, lawsone, menadione, methoxy-naphthoquinones, and others) to cellular and inter-cellular signaling processes are discussed: (i) naphthoquinone-induced Nrf2-dependent modulation of gene expression and its potentially beneficial outcome; (ii) the modulation of receptor tyrosine kinases, such as the epidermal growth factor receptor by naphthoquinones, resulting in altered gap junctional intercellular communication. Generation of reactive oxygen species and modulation of redox signaling are properties of naphthoquinones that render them interesting leads for the development of novel compounds of potential use in various therapeutic settings. MDPI 2014-09-17 /pmc/articles/PMC6270801/ /pubmed/25232709 http://dx.doi.org/10.3390/molecules190914902 Text en © 2014 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Klotz, Lars-Oliver Hou, Xiaoqing Jacob, Claus 1,4-Naphthoquinones: From Oxidative Damage to Cellular and Inter-Cellular Signaling |
title | 1,4-Naphthoquinones: From Oxidative Damage to Cellular and Inter-Cellular Signaling |
title_full | 1,4-Naphthoquinones: From Oxidative Damage to Cellular and Inter-Cellular Signaling |
title_fullStr | 1,4-Naphthoquinones: From Oxidative Damage to Cellular and Inter-Cellular Signaling |
title_full_unstemmed | 1,4-Naphthoquinones: From Oxidative Damage to Cellular and Inter-Cellular Signaling |
title_short | 1,4-Naphthoquinones: From Oxidative Damage to Cellular and Inter-Cellular Signaling |
title_sort | 1,4-naphthoquinones: from oxidative damage to cellular and inter-cellular signaling |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270801/ https://www.ncbi.nlm.nih.gov/pubmed/25232709 http://dx.doi.org/10.3390/molecules190914902 |
work_keys_str_mv | AT klotzlarsoliver 14naphthoquinonesfromoxidativedamagetocellularandintercellularsignaling AT houxiaoqing 14naphthoquinonesfromoxidativedamagetocellularandintercellularsignaling AT jacobclaus 14naphthoquinonesfromoxidativedamagetocellularandintercellularsignaling |