Cytotoxic Quinones from the Roots of Aloe dawei

Seven naphthoquinones and nine anthraquinones were isolated from the roots of Aloe dawei by chromatographic separation. The purified metabolites were identified by NMR and MS analyses. Out of the sixteen quinones, 6-hydroxy-3,5-dimethoxy-2-methyl-1,4-naphthoquinone is a new compound. Two of the isol...

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Detalles Bibliográficos
Autores principales: Abdissa, Negera, Induli, Martha, Fitzpatrick, Paul, Alao, John Patrick, Sunnerhagen, Per, Landberg, Göran, Yenesew, Abiy, Erdélyi, Máté
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270816/
https://www.ncbi.nlm.nih.gov/pubmed/24642911
http://dx.doi.org/10.3390/molecules19033264
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author Abdissa, Negera
Induli, Martha
Fitzpatrick, Paul
Alao, John Patrick
Sunnerhagen, Per
Landberg, Göran
Yenesew, Abiy
Erdélyi, Máté
author_facet Abdissa, Negera
Induli, Martha
Fitzpatrick, Paul
Alao, John Patrick
Sunnerhagen, Per
Landberg, Göran
Yenesew, Abiy
Erdélyi, Máté
author_sort Abdissa, Negera
collection PubMed
description Seven naphthoquinones and nine anthraquinones were isolated from the roots of Aloe dawei by chromatographic separation. The purified metabolites were identified by NMR and MS analyses. Out of the sixteen quinones, 6-hydroxy-3,5-dimethoxy-2-methyl-1,4-naphthoquinone is a new compound. Two of the isolates, 5,8-dihydroxy-3-methoxy-2-methylnaphthalene-1,4-dione and 1-hydroxy-8-methoxy-3-methylanthraquinone showed high cytotoxic activity (IC(50) 1.15 and 4.85 µM) on MCF-7 breast cancer cells, whereas the others showed moderate to low cytotoxic activity against MDA-MB-231 (ER Negative) and MCF-7 (ER Positive) cancer cells.
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spelling pubmed-62708162018-12-20 Cytotoxic Quinones from the Roots of Aloe dawei Abdissa, Negera Induli, Martha Fitzpatrick, Paul Alao, John Patrick Sunnerhagen, Per Landberg, Göran Yenesew, Abiy Erdélyi, Máté Molecules Article Seven naphthoquinones and nine anthraquinones were isolated from the roots of Aloe dawei by chromatographic separation. The purified metabolites were identified by NMR and MS analyses. Out of the sixteen quinones, 6-hydroxy-3,5-dimethoxy-2-methyl-1,4-naphthoquinone is a new compound. Two of the isolates, 5,8-dihydroxy-3-methoxy-2-methylnaphthalene-1,4-dione and 1-hydroxy-8-methoxy-3-methylanthraquinone showed high cytotoxic activity (IC(50) 1.15 and 4.85 µM) on MCF-7 breast cancer cells, whereas the others showed moderate to low cytotoxic activity against MDA-MB-231 (ER Negative) and MCF-7 (ER Positive) cancer cells. MDPI 2014-03-17 /pmc/articles/PMC6270816/ /pubmed/24642911 http://dx.doi.org/10.3390/molecules19033264 Text en © 2014 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Abdissa, Negera
Induli, Martha
Fitzpatrick, Paul
Alao, John Patrick
Sunnerhagen, Per
Landberg, Göran
Yenesew, Abiy
Erdélyi, Máté
Cytotoxic Quinones from the Roots of Aloe dawei
title Cytotoxic Quinones from the Roots of Aloe dawei
title_full Cytotoxic Quinones from the Roots of Aloe dawei
title_fullStr Cytotoxic Quinones from the Roots of Aloe dawei
title_full_unstemmed Cytotoxic Quinones from the Roots of Aloe dawei
title_short Cytotoxic Quinones from the Roots of Aloe dawei
title_sort cytotoxic quinones from the roots of aloe dawei
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270816/
https://www.ncbi.nlm.nih.gov/pubmed/24642911
http://dx.doi.org/10.3390/molecules19033264
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AT sunnerhagenper cytotoxicquinonesfromtherootsofaloedawei
AT landberggoran cytotoxicquinonesfromtherootsofaloedawei
AT yenesewabiy cytotoxicquinonesfromtherootsofaloedawei
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