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Antimicrobial Activities against Periodontopathic Bacteria of Pittosporum tobira and Its Active Compound
The study of medicinal plants for treatment of periodontitis is of great value to establish their efficacy as sources of new antimicrobial drugs. Five hundred and fifty eight Korean local plant extracts were screened for antibacterial activity against representative periodontopathic bacteria such as...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270877/ https://www.ncbi.nlm.nih.gov/pubmed/24662076 http://dx.doi.org/10.3390/molecules19033607 |
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author | Oh, Jung-Hyun Jeong, Yong Joon Koo, Hyun Jung Park, Dae Won Kang, Se Chan Khoa, Hoang Viet Bach Le, Le Ba Cho, Joon Hyeong Lee, Jin-Yong |
author_facet | Oh, Jung-Hyun Jeong, Yong Joon Koo, Hyun Jung Park, Dae Won Kang, Se Chan Khoa, Hoang Viet Bach Le, Le Ba Cho, Joon Hyeong Lee, Jin-Yong |
author_sort | Oh, Jung-Hyun |
collection | PubMed |
description | The study of medicinal plants for treatment of periodontitis is of great value to establish their efficacy as sources of new antimicrobial drugs. Five hundred and fifty eight Korean local plant extracts were screened for antibacterial activity against representative periodontopathic bacteria such as Porphyromonas gingivalis, Prevotella intermedia, and Fusobacterium nucleatum. Among the various medicinal plants, the alcohol extract of Pittosporum tobira, which significantly exhibited antibacterial effect for all tested strains, showed the highest activity in the antimicrobial assays. NMR analyses revealed that R1-barrigenol, a triterpene sapogenin, was the most effective compound in P. tobira. These results demonstrated that P. tobira possesses antimicrobial properties and would be beneficial for the prevention and treatment of periodontitis. |
format | Online Article Text |
id | pubmed-6270877 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62708772018-12-20 Antimicrobial Activities against Periodontopathic Bacteria of Pittosporum tobira and Its Active Compound Oh, Jung-Hyun Jeong, Yong Joon Koo, Hyun Jung Park, Dae Won Kang, Se Chan Khoa, Hoang Viet Bach Le, Le Ba Cho, Joon Hyeong Lee, Jin-Yong Molecules Article The study of medicinal plants for treatment of periodontitis is of great value to establish their efficacy as sources of new antimicrobial drugs. Five hundred and fifty eight Korean local plant extracts were screened for antibacterial activity against representative periodontopathic bacteria such as Porphyromonas gingivalis, Prevotella intermedia, and Fusobacterium nucleatum. Among the various medicinal plants, the alcohol extract of Pittosporum tobira, which significantly exhibited antibacterial effect for all tested strains, showed the highest activity in the antimicrobial assays. NMR analyses revealed that R1-barrigenol, a triterpene sapogenin, was the most effective compound in P. tobira. These results demonstrated that P. tobira possesses antimicrobial properties and would be beneficial for the prevention and treatment of periodontitis. MDPI 2014-03-24 /pmc/articles/PMC6270877/ /pubmed/24662076 http://dx.doi.org/10.3390/molecules19033607 Text en © 2014 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Oh, Jung-Hyun Jeong, Yong Joon Koo, Hyun Jung Park, Dae Won Kang, Se Chan Khoa, Hoang Viet Bach Le, Le Ba Cho, Joon Hyeong Lee, Jin-Yong Antimicrobial Activities against Periodontopathic Bacteria of Pittosporum tobira and Its Active Compound |
title | Antimicrobial Activities against Periodontopathic Bacteria of Pittosporum tobira and Its Active Compound |
title_full | Antimicrobial Activities against Periodontopathic Bacteria of Pittosporum tobira and Its Active Compound |
title_fullStr | Antimicrobial Activities against Periodontopathic Bacteria of Pittosporum tobira and Its Active Compound |
title_full_unstemmed | Antimicrobial Activities against Periodontopathic Bacteria of Pittosporum tobira and Its Active Compound |
title_short | Antimicrobial Activities against Periodontopathic Bacteria of Pittosporum tobira and Its Active Compound |
title_sort | antimicrobial activities against periodontopathic bacteria of pittosporum tobira and its active compound |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270877/ https://www.ncbi.nlm.nih.gov/pubmed/24662076 http://dx.doi.org/10.3390/molecules19033607 |
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