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Antimicrobial Activities against Periodontopathic Bacteria of Pittosporum tobira and Its Active Compound

The study of medicinal plants for treatment of periodontitis is of great value to establish their efficacy as sources of new antimicrobial drugs. Five hundred and fifty eight Korean local plant extracts were screened for antibacterial activity against representative periodontopathic bacteria such as...

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Autores principales: Oh, Jung-Hyun, Jeong, Yong Joon, Koo, Hyun Jung, Park, Dae Won, Kang, Se Chan, Khoa, Hoang Viet Bach, Le, Le Ba, Cho, Joon Hyeong, Lee, Jin-Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270877/
https://www.ncbi.nlm.nih.gov/pubmed/24662076
http://dx.doi.org/10.3390/molecules19033607
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author Oh, Jung-Hyun
Jeong, Yong Joon
Koo, Hyun Jung
Park, Dae Won
Kang, Se Chan
Khoa, Hoang Viet Bach
Le, Le Ba
Cho, Joon Hyeong
Lee, Jin-Yong
author_facet Oh, Jung-Hyun
Jeong, Yong Joon
Koo, Hyun Jung
Park, Dae Won
Kang, Se Chan
Khoa, Hoang Viet Bach
Le, Le Ba
Cho, Joon Hyeong
Lee, Jin-Yong
author_sort Oh, Jung-Hyun
collection PubMed
description The study of medicinal plants for treatment of periodontitis is of great value to establish their efficacy as sources of new antimicrobial drugs. Five hundred and fifty eight Korean local plant extracts were screened for antibacterial activity against representative periodontopathic bacteria such as Porphyromonas gingivalis, Prevotella intermedia, and Fusobacterium nucleatum. Among the various medicinal plants, the alcohol extract of Pittosporum tobira, which significantly exhibited antibacterial effect for all tested strains, showed the highest activity in the antimicrobial assays. NMR analyses revealed that R1-barrigenol, a triterpene sapogenin, was the most effective compound in P. tobira. These results demonstrated that P. tobira possesses antimicrobial properties and would be beneficial for the prevention and treatment of periodontitis.
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spelling pubmed-62708772018-12-20 Antimicrobial Activities against Periodontopathic Bacteria of Pittosporum tobira and Its Active Compound Oh, Jung-Hyun Jeong, Yong Joon Koo, Hyun Jung Park, Dae Won Kang, Se Chan Khoa, Hoang Viet Bach Le, Le Ba Cho, Joon Hyeong Lee, Jin-Yong Molecules Article The study of medicinal plants for treatment of periodontitis is of great value to establish their efficacy as sources of new antimicrobial drugs. Five hundred and fifty eight Korean local plant extracts were screened for antibacterial activity against representative periodontopathic bacteria such as Porphyromonas gingivalis, Prevotella intermedia, and Fusobacterium nucleatum. Among the various medicinal plants, the alcohol extract of Pittosporum tobira, which significantly exhibited antibacterial effect for all tested strains, showed the highest activity in the antimicrobial assays. NMR analyses revealed that R1-barrigenol, a triterpene sapogenin, was the most effective compound in P. tobira. These results demonstrated that P. tobira possesses antimicrobial properties and would be beneficial for the prevention and treatment of periodontitis. MDPI 2014-03-24 /pmc/articles/PMC6270877/ /pubmed/24662076 http://dx.doi.org/10.3390/molecules19033607 Text en © 2014 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Oh, Jung-Hyun
Jeong, Yong Joon
Koo, Hyun Jung
Park, Dae Won
Kang, Se Chan
Khoa, Hoang Viet Bach
Le, Le Ba
Cho, Joon Hyeong
Lee, Jin-Yong
Antimicrobial Activities against Periodontopathic Bacteria of Pittosporum tobira and Its Active Compound
title Antimicrobial Activities against Periodontopathic Bacteria of Pittosporum tobira and Its Active Compound
title_full Antimicrobial Activities against Periodontopathic Bacteria of Pittosporum tobira and Its Active Compound
title_fullStr Antimicrobial Activities against Periodontopathic Bacteria of Pittosporum tobira and Its Active Compound
title_full_unstemmed Antimicrobial Activities against Periodontopathic Bacteria of Pittosporum tobira and Its Active Compound
title_short Antimicrobial Activities against Periodontopathic Bacteria of Pittosporum tobira and Its Active Compound
title_sort antimicrobial activities against periodontopathic bacteria of pittosporum tobira and its active compound
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270877/
https://www.ncbi.nlm.nih.gov/pubmed/24662076
http://dx.doi.org/10.3390/molecules19033607
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