Trigocherrierin A, a Potent Inhibitor of Chikungunya Virus Replication

Trigocherrierin A (1) and trigocherriolide E (2), two new daphnane diterpenoid orthoesters (DDOs), and six chlorinated analogues, trigocherrins A, B, F and trigocherriolides A–C, were isolated from the leaves of Trigonostemon cherrieri. Their structures were identified by mass spectrometry, extensiv...

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Detalles Bibliográficos
Autores principales: Bourjot, Mélanie, Leyssen, Pieter, Neyts, Johan, Dumontet, Vincent, Litaudon, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270878/
https://www.ncbi.nlm.nih.gov/pubmed/24662077
http://dx.doi.org/10.3390/molecules19033617
Descripción
Sumario:Trigocherrierin A (1) and trigocherriolide E (2), two new daphnane diterpenoid orthoesters (DDOs), and six chlorinated analogues, trigocherrins A, B, F and trigocherriolides A–C, were isolated from the leaves of Trigonostemon cherrieri. Their structures were identified by mass spectrometry, extensive one- and two-dimensional NMR spectroscopy and through comparison with data reported in the literature. These compounds are potent and selective inhibitors of chikungunya virus (CHIKV) replication. Among the DDOs isolated, compound 1 exhibited the strongest anti-CHIKV activity (EC(50) = 0.6 ± 0.1 µM, SI = 71.7).

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