Trigocherrierin A, a Potent Inhibitor of Chikungunya Virus Replication

Trigocherrierin A (1) and trigocherriolide E (2), two new daphnane diterpenoid orthoesters (DDOs), and six chlorinated analogues, trigocherrins A, B, F and trigocherriolides A–C, were isolated from the leaves of Trigonostemon cherrieri. Their structures were identified by mass spectrometry, extensiv...

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Autores principales: Bourjot, Mélanie, Leyssen, Pieter, Neyts, Johan, Dumontet, Vincent, Litaudon, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270878/
https://www.ncbi.nlm.nih.gov/pubmed/24662077
http://dx.doi.org/10.3390/molecules19033617
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author Bourjot, Mélanie
Leyssen, Pieter
Neyts, Johan
Dumontet, Vincent
Litaudon, Marc
author_facet Bourjot, Mélanie
Leyssen, Pieter
Neyts, Johan
Dumontet, Vincent
Litaudon, Marc
author_sort Bourjot, Mélanie
collection PubMed
description Trigocherrierin A (1) and trigocherriolide E (2), two new daphnane diterpenoid orthoesters (DDOs), and six chlorinated analogues, trigocherrins A, B, F and trigocherriolides A–C, were isolated from the leaves of Trigonostemon cherrieri. Their structures were identified by mass spectrometry, extensive one- and two-dimensional NMR spectroscopy and through comparison with data reported in the literature. These compounds are potent and selective inhibitors of chikungunya virus (CHIKV) replication. Among the DDOs isolated, compound 1 exhibited the strongest anti-CHIKV activity (EC(50) = 0.6 ± 0.1 µM, SI = 71.7).
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spelling pubmed-62708782018-12-20 Trigocherrierin A, a Potent Inhibitor of Chikungunya Virus Replication Bourjot, Mélanie Leyssen, Pieter Neyts, Johan Dumontet, Vincent Litaudon, Marc Molecules Article Trigocherrierin A (1) and trigocherriolide E (2), two new daphnane diterpenoid orthoesters (DDOs), and six chlorinated analogues, trigocherrins A, B, F and trigocherriolides A–C, were isolated from the leaves of Trigonostemon cherrieri. Their structures were identified by mass spectrometry, extensive one- and two-dimensional NMR spectroscopy and through comparison with data reported in the literature. These compounds are potent and selective inhibitors of chikungunya virus (CHIKV) replication. Among the DDOs isolated, compound 1 exhibited the strongest anti-CHIKV activity (EC(50) = 0.6 ± 0.1 µM, SI = 71.7). MDPI 2014-03-24 /pmc/articles/PMC6270878/ /pubmed/24662077 http://dx.doi.org/10.3390/molecules19033617 Text en © 2014 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Bourjot, Mélanie
Leyssen, Pieter
Neyts, Johan
Dumontet, Vincent
Litaudon, Marc
Trigocherrierin A, a Potent Inhibitor of Chikungunya Virus Replication
title Trigocherrierin A, a Potent Inhibitor of Chikungunya Virus Replication
title_full Trigocherrierin A, a Potent Inhibitor of Chikungunya Virus Replication
title_fullStr Trigocherrierin A, a Potent Inhibitor of Chikungunya Virus Replication
title_full_unstemmed Trigocherrierin A, a Potent Inhibitor of Chikungunya Virus Replication
title_short Trigocherrierin A, a Potent Inhibitor of Chikungunya Virus Replication
title_sort trigocherrierin a, a potent inhibitor of chikungunya virus replication
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270878/
https://www.ncbi.nlm.nih.gov/pubmed/24662077
http://dx.doi.org/10.3390/molecules19033617
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