Cargando…
Intraoperative Blood Transfusion and Postoperative Morbidity Following Liver Resection
BACKGROUND: Blood transfusion is common during liver resection (LR). The objective of the present study was to investigate the effects of intraoperative transfusion of different blood components on post-LR morbidity. MATERIAL/METHODS: We included 610 patients undergoing LR and grouped them according...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scientific Literature, Inc.
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270889/ https://www.ncbi.nlm.nih.gov/pubmed/30470732 http://dx.doi.org/10.12659/MSM.910978 |
_version_ | 1783376802663628800 |
---|---|
author | Lu, Qiang Zhang, Jing Gao, Wei-Man Lv, Yi Zhang, Xu-Feng Liu, Xue-Min |
author_facet | Lu, Qiang Zhang, Jing Gao, Wei-Man Lv, Yi Zhang, Xu-Feng Liu, Xue-Min |
author_sort | Lu, Qiang |
collection | PubMed |
description | BACKGROUND: Blood transfusion is common during liver resection (LR). The objective of the present study was to investigate the effects of intraoperative transfusion of different blood components on post-LR morbidity. MATERIAL/METHODS: We included 610 patients undergoing LR and grouped them according to intraoperative transfusion of different blood components: packed red blood cells only (PRBC, n=81); frozen fresh plasma, platelets, and cryoprecipitate (FPC, n=38); transfusion only with PRBC + FPC transfusion (n=244); and no blood transfusion (n=247). Propensity score matching (PSM) analysis was used to mitigate selection bias in comparisons. RESULTS: The overall blood transfusion rate was 59.5%. In comparison with the no blood transfusion group, PRBC-only and PRBC + FPC transfusion were more common in patients with lower preoperative hemoglobin, worse liver function, larger tumor size, and undergoing a major LR, and thus were associated with increased postoperative morbidity. In contrast, FPC-only transfusion was more frequent in patients with a liver function of Child-Pugh B and lower preoperative albumin vs. the no blood transfusion group. In the propensity model, transfusion of PRBC (PRBC-only and PRBC+FPC) and FPC (FPC-only and FPC+PRBC) were significantly associated with increased postoperative complications vs. the no blood transfusion group (OR and 95% CI, 1.9 [1.2–2.7], p=0.002; OR and 95% CI, 1.6 [1.0–2.4], p=0.029). In contrast, intraoperative PRBC-only or FPC-only transfusion showed no significant adverse effects on postoperative morbidity. CONCLUSIONS: Allogenic transfusion of PRBC and FPC blood components was associated with increased postoperative morbidity after liver surgery. Different blood components should be used only when absolutely necessary. |
format | Online Article Text |
id | pubmed-6270889 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | International Scientific Literature, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-62708892018-12-21 Intraoperative Blood Transfusion and Postoperative Morbidity Following Liver Resection Lu, Qiang Zhang, Jing Gao, Wei-Man Lv, Yi Zhang, Xu-Feng Liu, Xue-Min Med Sci Monit Clinical Research BACKGROUND: Blood transfusion is common during liver resection (LR). The objective of the present study was to investigate the effects of intraoperative transfusion of different blood components on post-LR morbidity. MATERIAL/METHODS: We included 610 patients undergoing LR and grouped them according to intraoperative transfusion of different blood components: packed red blood cells only (PRBC, n=81); frozen fresh plasma, platelets, and cryoprecipitate (FPC, n=38); transfusion only with PRBC + FPC transfusion (n=244); and no blood transfusion (n=247). Propensity score matching (PSM) analysis was used to mitigate selection bias in comparisons. RESULTS: The overall blood transfusion rate was 59.5%. In comparison with the no blood transfusion group, PRBC-only and PRBC + FPC transfusion were more common in patients with lower preoperative hemoglobin, worse liver function, larger tumor size, and undergoing a major LR, and thus were associated with increased postoperative morbidity. In contrast, FPC-only transfusion was more frequent in patients with a liver function of Child-Pugh B and lower preoperative albumin vs. the no blood transfusion group. In the propensity model, transfusion of PRBC (PRBC-only and PRBC+FPC) and FPC (FPC-only and FPC+PRBC) were significantly associated with increased postoperative complications vs. the no blood transfusion group (OR and 95% CI, 1.9 [1.2–2.7], p=0.002; OR and 95% CI, 1.6 [1.0–2.4], p=0.029). In contrast, intraoperative PRBC-only or FPC-only transfusion showed no significant adverse effects on postoperative morbidity. CONCLUSIONS: Allogenic transfusion of PRBC and FPC blood components was associated with increased postoperative morbidity after liver surgery. Different blood components should be used only when absolutely necessary. International Scientific Literature, Inc. 2018-11-24 /pmc/articles/PMC6270889/ /pubmed/30470732 http://dx.doi.org/10.12659/MSM.910978 Text en © Med Sci Monit, 2018 This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) ) |
spellingShingle | Clinical Research Lu, Qiang Zhang, Jing Gao, Wei-Man Lv, Yi Zhang, Xu-Feng Liu, Xue-Min Intraoperative Blood Transfusion and Postoperative Morbidity Following Liver Resection |
title | Intraoperative Blood Transfusion and Postoperative Morbidity Following Liver Resection |
title_full | Intraoperative Blood Transfusion and Postoperative Morbidity Following Liver Resection |
title_fullStr | Intraoperative Blood Transfusion and Postoperative Morbidity Following Liver Resection |
title_full_unstemmed | Intraoperative Blood Transfusion and Postoperative Morbidity Following Liver Resection |
title_short | Intraoperative Blood Transfusion and Postoperative Morbidity Following Liver Resection |
title_sort | intraoperative blood transfusion and postoperative morbidity following liver resection |
topic | Clinical Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270889/ https://www.ncbi.nlm.nih.gov/pubmed/30470732 http://dx.doi.org/10.12659/MSM.910978 |
work_keys_str_mv | AT luqiang intraoperativebloodtransfusionandpostoperativemorbidityfollowingliverresection AT zhangjing intraoperativebloodtransfusionandpostoperativemorbidityfollowingliverresection AT gaoweiman intraoperativebloodtransfusionandpostoperativemorbidityfollowingliverresection AT lvyi intraoperativebloodtransfusionandpostoperativemorbidityfollowingliverresection AT zhangxufeng intraoperativebloodtransfusionandpostoperativemorbidityfollowingliverresection AT liuxuemin intraoperativebloodtransfusionandpostoperativemorbidityfollowingliverresection |