Easy Access to Evans’ Oxazolidinones. Stereoselective Synthesis and Antibacterial Activity of a New 2-Oxazolidinone Derivative

An interesting new approach was developed for the synthesis of Evans’ chiral auxiliaries with excellent yields. In turn, another new stereoselective and efficient strategy has also allowed for the preparation of a 2-oxazolidinone derivative in 34% overall yield from the Morita-Baylis-Hillman adduct....

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Detalles Bibliográficos
Autores principales: Diaz, Gaspar, de Freitas, Michelle A. A., Ricci-Silva, Maria E., Diaz, Marisa A. N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270906/
https://www.ncbi.nlm.nih.gov/pubmed/24914892
http://dx.doi.org/10.3390/molecules19067429
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author Diaz, Gaspar
de Freitas, Michelle A. A.
Ricci-Silva, Maria E.
Diaz, Marisa A. N.
author_facet Diaz, Gaspar
de Freitas, Michelle A. A.
Ricci-Silva, Maria E.
Diaz, Marisa A. N.
author_sort Diaz, Gaspar
collection PubMed
description An interesting new approach was developed for the synthesis of Evans’ chiral auxiliaries with excellent yields. In turn, another new stereoselective and efficient strategy has also allowed for the preparation of a 2-oxazolidinone derivative in 34% overall yield from the Morita-Baylis-Hillman adduct. The antibacterial activity of this oxazolidinone was tested against Staphylococcus aureus strains isolated from animals with mastitis infections.
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spelling pubmed-62709062018-12-21 Easy Access to Evans’ Oxazolidinones. Stereoselective Synthesis and Antibacterial Activity of a New 2-Oxazolidinone Derivative Diaz, Gaspar de Freitas, Michelle A. A. Ricci-Silva, Maria E. Diaz, Marisa A. N. Molecules Article An interesting new approach was developed for the synthesis of Evans’ chiral auxiliaries with excellent yields. In turn, another new stereoselective and efficient strategy has also allowed for the preparation of a 2-oxazolidinone derivative in 34% overall yield from the Morita-Baylis-Hillman adduct. The antibacterial activity of this oxazolidinone was tested against Staphylococcus aureus strains isolated from animals with mastitis infections. MDPI 2014-06-06 /pmc/articles/PMC6270906/ /pubmed/24914892 http://dx.doi.org/10.3390/molecules19067429 Text en © 2014 by the authors. licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Diaz, Gaspar
de Freitas, Michelle A. A.
Ricci-Silva, Maria E.
Diaz, Marisa A. N.
Easy Access to Evans’ Oxazolidinones. Stereoselective Synthesis and Antibacterial Activity of a New 2-Oxazolidinone Derivative
title Easy Access to Evans’ Oxazolidinones. Stereoselective Synthesis and Antibacterial Activity of a New 2-Oxazolidinone Derivative
title_full Easy Access to Evans’ Oxazolidinones. Stereoselective Synthesis and Antibacterial Activity of a New 2-Oxazolidinone Derivative
title_fullStr Easy Access to Evans’ Oxazolidinones. Stereoselective Synthesis and Antibacterial Activity of a New 2-Oxazolidinone Derivative
title_full_unstemmed Easy Access to Evans’ Oxazolidinones. Stereoselective Synthesis and Antibacterial Activity of a New 2-Oxazolidinone Derivative
title_short Easy Access to Evans’ Oxazolidinones. Stereoselective Synthesis and Antibacterial Activity of a New 2-Oxazolidinone Derivative
title_sort easy access to evans’ oxazolidinones. stereoselective synthesis and antibacterial activity of a new 2-oxazolidinone derivative
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270906/
https://www.ncbi.nlm.nih.gov/pubmed/24914892
http://dx.doi.org/10.3390/molecules19067429
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