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A New Urease Inhibitor from Viola betonicifolia

Urease has attracted much attention, as it is directly involved in the formation of infection stones and contributes to the pathogenesis of urolithiasis, pyelonephritis, ammonia and hepatic encephalopathy, hepatic coma and urinary catheter encrustation. Moreover, urease is the major cause of patholo...

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Detalles Bibliográficos
Autores principales: Muhammad, Naveed, Saeed, Muhammad, Khan, Ajmal, Adhikari, Achyut, Wadood, Abdul, Khan, Khalid Mohammed, De Feo, Vincenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270924/
https://www.ncbi.nlm.nih.gov/pubmed/25329870
http://dx.doi.org/10.3390/molecules191016770
Descripción
Sumario:Urease has attracted much attention, as it is directly involved in the formation of infection stones and contributes to the pathogenesis of urolithiasis, pyelonephritis, ammonia and hepatic encephalopathy, hepatic coma and urinary catheter encrustation. Moreover, urease is the major cause of pathologies induced by H. pylori, such as gastritis and peptic ulcer. In the present work, the new natural compound, 3-methoxydalbergione, was isolated from Viola betonicifolia. A mechanistic study of this compound as a natural urease inhibitor was performed by using enzyme kinetics and docking studies. 3-Methoxydalbergione could be considered as a lead molecule for drugs useful in the urease associated diseases.