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A New Urease Inhibitor from Viola betonicifolia
Urease has attracted much attention, as it is directly involved in the formation of infection stones and contributes to the pathogenesis of urolithiasis, pyelonephritis, ammonia and hepatic encephalopathy, hepatic coma and urinary catheter encrustation. Moreover, urease is the major cause of patholo...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270924/ https://www.ncbi.nlm.nih.gov/pubmed/25329870 http://dx.doi.org/10.3390/molecules191016770 |
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author | Muhammad, Naveed Saeed, Muhammad Khan, Ajmal Adhikari, Achyut Wadood, Abdul Khan, Khalid Mohammed De Feo, Vincenzo |
author_facet | Muhammad, Naveed Saeed, Muhammad Khan, Ajmal Adhikari, Achyut Wadood, Abdul Khan, Khalid Mohammed De Feo, Vincenzo |
author_sort | Muhammad, Naveed |
collection | PubMed |
description | Urease has attracted much attention, as it is directly involved in the formation of infection stones and contributes to the pathogenesis of urolithiasis, pyelonephritis, ammonia and hepatic encephalopathy, hepatic coma and urinary catheter encrustation. Moreover, urease is the major cause of pathologies induced by H. pylori, such as gastritis and peptic ulcer. In the present work, the new natural compound, 3-methoxydalbergione, was isolated from Viola betonicifolia. A mechanistic study of this compound as a natural urease inhibitor was performed by using enzyme kinetics and docking studies. 3-Methoxydalbergione could be considered as a lead molecule for drugs useful in the urease associated diseases. |
format | Online Article Text |
id | pubmed-6270924 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62709242018-12-27 A New Urease Inhibitor from Viola betonicifolia Muhammad, Naveed Saeed, Muhammad Khan, Ajmal Adhikari, Achyut Wadood, Abdul Khan, Khalid Mohammed De Feo, Vincenzo Molecules Article Urease has attracted much attention, as it is directly involved in the formation of infection stones and contributes to the pathogenesis of urolithiasis, pyelonephritis, ammonia and hepatic encephalopathy, hepatic coma and urinary catheter encrustation. Moreover, urease is the major cause of pathologies induced by H. pylori, such as gastritis and peptic ulcer. In the present work, the new natural compound, 3-methoxydalbergione, was isolated from Viola betonicifolia. A mechanistic study of this compound as a natural urease inhibitor was performed by using enzyme kinetics and docking studies. 3-Methoxydalbergione could be considered as a lead molecule for drugs useful in the urease associated diseases. MDPI 2014-10-17 /pmc/articles/PMC6270924/ /pubmed/25329870 http://dx.doi.org/10.3390/molecules191016770 Text en © 2014 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Muhammad, Naveed Saeed, Muhammad Khan, Ajmal Adhikari, Achyut Wadood, Abdul Khan, Khalid Mohammed De Feo, Vincenzo A New Urease Inhibitor from Viola betonicifolia |
title | A New Urease Inhibitor from Viola betonicifolia |
title_full | A New Urease Inhibitor from Viola betonicifolia |
title_fullStr | A New Urease Inhibitor from Viola betonicifolia |
title_full_unstemmed | A New Urease Inhibitor from Viola betonicifolia |
title_short | A New Urease Inhibitor from Viola betonicifolia |
title_sort | new urease inhibitor from viola betonicifolia |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270924/ https://www.ncbi.nlm.nih.gov/pubmed/25329870 http://dx.doi.org/10.3390/molecules191016770 |
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