Cargando…

Design and Synthesis of a Series of Truncated Neplanocin Fleximers

In an effort to study the effects of flexibility on enzyme recognition and activity, we have developed several different series of flexible nucleoside analogues in which the purine base is split into its respective imidazole and pyrimidine components. The focus of this particular study was to synthe...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zimmermann, Sarah C., O’Neill, Elizaveta, Ebiloma, Godwin U., Wallace, Lynsey J. M., De Koning, Harry P., Seley-Radtke, Katherine L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2014
Materias:	Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270936/ https://www.ncbi.nlm.nih.gov/pubmed/25521119 http://dx.doi.org/10.3390/molecules191221200

Ejemplares similares

Design, synthesis and evaluation of a series of acyclic fleximer nucleoside analogues with anti-coronavirus activity
por: Peters, Hannah L., et al.
Publicado: (2015)

Synthesis of distal and proximal fleximer base analogues and evaluation in the nucleocapsid protein of HIV-1
por: Ku, Therese, et al.
Publicado: (2019)

Synthesis of New 5′-Norcarbocyclic Aza/Deaza Purine Fleximers - Noncompetitive Inhibitors of E.coli Purine Nucleoside Phosphorylase
por: Khandazhinskaya, Anastasia, et al.
Publicado: (2022)

Probing the Effects of Pyrimidine Functional Group Switches on Acyclic Fleximer Analogues for Antiviral Activity
por: Yates, Mary K., et al.
Publicado: (2019)

Nucleoside Analogs with Fleximer Nucleobase
por: Chudinov, Mikhail V.
Publicado: (2020)

Discovery, Design, Synthesis, and Application of Nucleoside/Nucleotides
por: Seley-Radtke, Katherine
Publicado: (2020)

Synthesis of a Pyridone-Based Phthalimide Fleximer and Its Characterization and Supramolecular Property Evaluation
por: Dowarah, Jayanta, et al.
Publicado: (2022)

A novel route to a chiral building block for the preparation of cyclopentenyl carbocyclic nucleosides. Synthesis and anticancer activity of enantiomeric neplanocins A
por: Łukasik, Beata, et al.
Publicado: (2020)

Antiproliferative and Antimigration Activities of Fluoro-Neplanocin A via Inhibition of Histone H3 Methylation in Triple-Negative Breast Cancer
por: Byun, Woong Sub, et al.
Publicado: (2020)

Multi-target mode of action of a Clerodane-type diterpenoid from Polyalthia longifolia targeting African trypanosomes
por: Ebiloma, Godwin U., et al.
Publicado: (2018)

Flexibility—Not just for yoga anymore!
por: Seley-Radtke, Katherine
Publicado: (2018)

Small molecule antivirals – Still our best hope for a cure
por: Seley-Radtke, Katherine
Publicado: (2020)

Preface
por: Seley-Radtke, Katherine
Publicado: (2021)

The Strong Anti-Kinetoplastid Properties of Bee Propolis: Composition and Identification of the Active Agents and Their Biochemical Targets
por: Ebiloma, Godwin U., et al.
Publicado: (2020)

A Review of the Antimalarial, Antitrypanosomal, and Antileishmanial Activities of Natural Compounds Isolated From Nigerian Flora
por: Ungogo, Marzuq A., et al.
Publicado: (2020)

Synthesis of 3-hetarylpyrroles by Suzuki–Miyaura cross-coupling
por: Matyugina, Elena S., et al.
Publicado: (2020)

Advances in antiviral nucleoside analogues and their prodrugs
por: Seley-Radtke, Katherine, et al.
Publicado: (2018)

Design and Synthesis of New Modified Flexible Purine Bases as Potential Inhibitors of Human PNP
por: Khandazhinskaya, Anastasia, et al.
Publicado: (2023)

Recent advances in synthetic approaches for medicinal chemistry of C-nucleosides
por: Temburnikar, Kartik, et al.
Publicado: (2018)

Potent Antitrypanosomal Activities of 3-Aminosteroids against African Trypanosomes: Investigation of Cellular Effects and of Cross-Resistance with Existing Drugs
por: Nnadi, Charles O., et al.
Publicado: (2019)

The evolution of antiviral nucleoside analogues: A review for chemists and non-chemists. Part II: Complex modifications to the nucleoside scaffold
por: Yates, Mary K., et al.
Publicado: (2019)

The evolution of nucleoside analogue antivirals: A review for chemists and non-chemists. Part 1: Early structural modifications to the nucleoside scaffold
por: Seley-Radtke, Katherine L., et al.
Publicado: (2018)

Structural and Biological Investigations for a Series of N-5 Substituted Pyrrolo[3,2-d]pyrimidines as Potential Anti-Cancer Therapeutics
por: Cawrse, Brian M., et al.
Publicado: (2019)

European propolis is highly active against trypanosomatids including Crithidia fasciculata
por: Alotaibi, Abdullah, et al.
Publicado: (2019)

Broad spectrum antiviral nucleosides—Our best hope for the future
por: Seley-Radtke, Katherine L., et al.
Publicado: (2021)

A highly facile approach to the synthesis of novel 2-(3-benzyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-N-phenylacetamides
por: Novikov, Mikhail S., et al.
Publicado: (2013)

Hyperbolic Cross Truncations for Stochastic Fourier Cosine Series
por: Zhang, Zhihua
Publicado: (2014)

Nucleoside analogs as a rich source of antiviral agents active against arthropod-borne flaviviruses
por: Eyer, Luděk, et al.
Publicado: (2018)

Novel 1-[5-(4-bromophenoxy)pentyl]-3-(2-arylamino- 2-oxoethyl)uracils and their antiviral properties
por: Paramonova, Maria P., et al.
Publicado: (2017)

Targeting the Parasite's DNA with Methyltriazenyl Purine Analogs Is a Safe, Selective, and Efficacious Antitrypanosomal Strategy
por: Rodenko, Boris, et al.
Publicado: (2015)

Functional and structural analysis of AT-specific minor groove binders that disrupt DNA–protein interactions and cause disintegration of the Trypanosoma brucei kinetoplast
por: Millan, Cinthia R., et al.
Publicado: (2017)

Toward the discovery of dual HCMV–VZV inhibitors: Synthesis, structure activity relationship analysis, and cytotoxicity studies of long chained 2-uracil-3-yl-N-(4-phenoxyphenyl)acetamides
por: Babkov, Denis A., et al.
Publicado: (2015)

Imidazoline- and Benzamidine-Based Trypanosome Alternative Oxidase Inhibitors: Synthesis and Structure–Activity Relationship Studies
por: Cisneros, David, et al.
Publicado: (2022)

The Chemical Characterization of Nigerian Propolis samples and Their Activity Against Trypanosoma brucei
por: Omar, Ruwida, et al.
Publicado: (2017)

The Antiprotozoal Activity of Papua New Guinea Propolis and Its Triterpenes
por: Alenezi, Samya S., et al.
Publicado: (2022)

Activity of Compounds from Temperate Propolis against Trypanosoma brucei and Leishmania mexicana
por: Alotaibi, Adullah, et al.
Publicado: (2021)

The Activity of Red Nigerian Propolis and Some of Its Components against Trypanosoma brucei and Trypanosoma congolense
por: Alenezi, Samya S., et al.
Publicado: (2023)

The Synthesis of Truncated Polypeptides for Immune Surveillance and Viral Evasion
por: Cardinaud, Sylvain, et al.
Publicado: (2010)

Synthesis and anti-HCMV activity of 1-[ω-(phenoxy)alkyl]uracil derivatives and analogues thereof
por: Novikov, Mikhail S., et al.
Publicado: (2013)

The use of truncated Taylor maps in dynamic aperture studies
por: Kleiss, R H, et al.
Publicado: (1993)

Cannot write session to /tmp/vufind_sessions/sess_l6hf426gbtnet1fktf3l862nmj