Bioactive Profiles, Antioxidant Activities, Nitrite Scavenging Capacities and Protective Effects on H(2)O(2)-Injured PC12 Cells of Glycyrrhiza Glabra L. Leaf and Root Extracts

This study compared the total flavonoid content of Glycyrrhiza glabra L. leaf and root extracts. Results suggested that the total flavonoid content in the leaf extract was obviously higher than that in the root extract. Pinocembrin, the main compound in the leaf extract after purification by column...

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Detalles Bibliográficos
Autores principales: Dong, Yi, Zhao, Mouming, Zhao, Tiantian, Feng, Mengying, Chen, Huiping, Zhuang, Mingzhu, Lin, Lianzhu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270937/
https://www.ncbi.nlm.nih.gov/pubmed/24983860
http://dx.doi.org/10.3390/molecules19079101
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author Dong, Yi
Zhao, Mouming
Zhao, Tiantian
Feng, Mengying
Chen, Huiping
Zhuang, Mingzhu
Lin, Lianzhu
author_facet Dong, Yi
Zhao, Mouming
Zhao, Tiantian
Feng, Mengying
Chen, Huiping
Zhuang, Mingzhu
Lin, Lianzhu
author_sort Dong, Yi
collection PubMed
description This study compared the total flavonoid content of Glycyrrhiza glabra L. leaf and root extracts. Results suggested that the total flavonoid content in the leaf extract was obviously higher than that in the root extract. Pinocembrin, the main compound in the leaf extract after purification by column chromatography, showed good antioxidant activity and nitrite scavenging capacity, but moderate inhibitory effect on mushroom tyrosinase. Liquiritin was the main compound in root extract and possessed strong inhibitory effect on mushroom tyrosinase. Both compounds exhibited significant protection effect on H(2)O(2)-injured PC12 cells at a low concentration. These results indicate that Glycyrrhiza glabra L. leaf is potential as an important raw material for functional food.
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spelling pubmed-62709372018-12-21 Bioactive Profiles, Antioxidant Activities, Nitrite Scavenging Capacities and Protective Effects on H(2)O(2)-Injured PC12 Cells of Glycyrrhiza Glabra L. Leaf and Root Extracts Dong, Yi Zhao, Mouming Zhao, Tiantian Feng, Mengying Chen, Huiping Zhuang, Mingzhu Lin, Lianzhu Molecules Article This study compared the total flavonoid content of Glycyrrhiza glabra L. leaf and root extracts. Results suggested that the total flavonoid content in the leaf extract was obviously higher than that in the root extract. Pinocembrin, the main compound in the leaf extract after purification by column chromatography, showed good antioxidant activity and nitrite scavenging capacity, but moderate inhibitory effect on mushroom tyrosinase. Liquiritin was the main compound in root extract and possessed strong inhibitory effect on mushroom tyrosinase. Both compounds exhibited significant protection effect on H(2)O(2)-injured PC12 cells at a low concentration. These results indicate that Glycyrrhiza glabra L. leaf is potential as an important raw material for functional food. MDPI 2014-06-30 /pmc/articles/PMC6270937/ /pubmed/24983860 http://dx.doi.org/10.3390/molecules19079101 Text en © 2014 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Dong, Yi
Zhao, Mouming
Zhao, Tiantian
Feng, Mengying
Chen, Huiping
Zhuang, Mingzhu
Lin, Lianzhu
Bioactive Profiles, Antioxidant Activities, Nitrite Scavenging Capacities and Protective Effects on H(2)O(2)-Injured PC12 Cells of Glycyrrhiza Glabra L. Leaf and Root Extracts
title Bioactive Profiles, Antioxidant Activities, Nitrite Scavenging Capacities and Protective Effects on H(2)O(2)-Injured PC12 Cells of Glycyrrhiza Glabra L. Leaf and Root Extracts
title_full Bioactive Profiles, Antioxidant Activities, Nitrite Scavenging Capacities and Protective Effects on H(2)O(2)-Injured PC12 Cells of Glycyrrhiza Glabra L. Leaf and Root Extracts
title_fullStr Bioactive Profiles, Antioxidant Activities, Nitrite Scavenging Capacities and Protective Effects on H(2)O(2)-Injured PC12 Cells of Glycyrrhiza Glabra L. Leaf and Root Extracts
title_full_unstemmed Bioactive Profiles, Antioxidant Activities, Nitrite Scavenging Capacities and Protective Effects on H(2)O(2)-Injured PC12 Cells of Glycyrrhiza Glabra L. Leaf and Root Extracts
title_short Bioactive Profiles, Antioxidant Activities, Nitrite Scavenging Capacities and Protective Effects on H(2)O(2)-Injured PC12 Cells of Glycyrrhiza Glabra L. Leaf and Root Extracts
title_sort bioactive profiles, antioxidant activities, nitrite scavenging capacities and protective effects on h(2)o(2)-injured pc12 cells of glycyrrhiza glabra l. leaf and root extracts
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270937/
https://www.ncbi.nlm.nih.gov/pubmed/24983860
http://dx.doi.org/10.3390/molecules19079101
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