Alkaloids from Marine Invertebrates as Important Leads for Anticancer Drugs Discovery and Development

The present review describes research on novel natural antitumor alkaloids isolated from marine invertebrates. The structure, origin, and confirmed cytotoxic activity of more than 130 novel alkaloids belonging to several structural families (indoles, pyrroles, pyrazines, quinolines, and pyridoacridi...

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Autores principales: Imperatore, Concetta, Aiello, Anna, D’Aniello, Filomena, Senese, Maria, Menna, Marialuisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270949/
https://www.ncbi.nlm.nih.gov/pubmed/25490431
http://dx.doi.org/10.3390/molecules191220391
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author Imperatore, Concetta
Aiello, Anna
D’Aniello, Filomena
Senese, Maria
Menna, Marialuisa
author_facet Imperatore, Concetta
Aiello, Anna
D’Aniello, Filomena
Senese, Maria
Menna, Marialuisa
author_sort Imperatore, Concetta
collection PubMed
description The present review describes research on novel natural antitumor alkaloids isolated from marine invertebrates. The structure, origin, and confirmed cytotoxic activity of more than 130 novel alkaloids belonging to several structural families (indoles, pyrroles, pyrazines, quinolines, and pyridoacridines), together with some of their synthetic analogs, are illustrated. Recent discoveries concerning the current state of the potential and/or development of some of them as new drugs, as well as the current knowledge regarding their modes of action, are also summarized. A special emphasis is given to the role of marine invertebrate alkaloids as an important source of leads for anticancer drug discovery.
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spelling pubmed-62709492018-12-28 Alkaloids from Marine Invertebrates as Important Leads for Anticancer Drugs Discovery and Development Imperatore, Concetta Aiello, Anna D’Aniello, Filomena Senese, Maria Menna, Marialuisa Molecules Review The present review describes research on novel natural antitumor alkaloids isolated from marine invertebrates. The structure, origin, and confirmed cytotoxic activity of more than 130 novel alkaloids belonging to several structural families (indoles, pyrroles, pyrazines, quinolines, and pyridoacridines), together with some of their synthetic analogs, are illustrated. Recent discoveries concerning the current state of the potential and/or development of some of them as new drugs, as well as the current knowledge regarding their modes of action, are also summarized. A special emphasis is given to the role of marine invertebrate alkaloids as an important source of leads for anticancer drug discovery. MDPI 2014-12-05 /pmc/articles/PMC6270949/ /pubmed/25490431 http://dx.doi.org/10.3390/molecules191220391 Text en © 2014 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Imperatore, Concetta
Aiello, Anna
D’Aniello, Filomena
Senese, Maria
Menna, Marialuisa
Alkaloids from Marine Invertebrates as Important Leads for Anticancer Drugs Discovery and Development
title Alkaloids from Marine Invertebrates as Important Leads for Anticancer Drugs Discovery and Development
title_full Alkaloids from Marine Invertebrates as Important Leads for Anticancer Drugs Discovery and Development
title_fullStr Alkaloids from Marine Invertebrates as Important Leads for Anticancer Drugs Discovery and Development
title_full_unstemmed Alkaloids from Marine Invertebrates as Important Leads for Anticancer Drugs Discovery and Development
title_short Alkaloids from Marine Invertebrates as Important Leads for Anticancer Drugs Discovery and Development
title_sort alkaloids from marine invertebrates as important leads for anticancer drugs discovery and development
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270949/
https://www.ncbi.nlm.nih.gov/pubmed/25490431
http://dx.doi.org/10.3390/molecules191220391
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