Polylactide Conjugates of Camptothecin with Different Drug Release Abilities

Camptothecin-polylactide conjugates (CMPT-PLA) were synthesized by covalent incorporation of CMPT into PLA of different microstructure, i.e., atactic PLA and atactic-block-isotactically enriched PLA (P(m) = 0.79) via urethane bonds. The kinetic release of CPMT from CMPT-PLA conjugates, tested in vit...

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Detalles Bibliográficos
Autores principales: Oledzka, Ewa, Horeglad, Paweł, Gruszczyńska, Zuzanna, Plichta, Andrzej, Nałęcz-Jawecki, Grzegorz, Sobczak, Marcin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270997/
https://www.ncbi.nlm.nih.gov/pubmed/25429566
http://dx.doi.org/10.3390/molecules191219460
Descripción
Sumario:Camptothecin-polylactide conjugates (CMPT-PLA) were synthesized by covalent incorporation of CMPT into PLA of different microstructure, i.e., atactic PLA and atactic-block-isotactically enriched PLA (P(m) = 0.79) via urethane bonds. The kinetic release of CPMT from CMPT-PLA conjugates, tested in vitro under different conditions, is possible in both cases and notably, strongly dependent on PLA microstructure. It shows that release properties of drug-PLA conjugates can be tailored by controlled design of the PLA microstructure, and allow in the case of CMPT-PLA conjugates for the development of highly controlled biodegradable CMPT systems—important delivery systems for anti-cancer agents.

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