Polylactide Conjugates of Camptothecin with Different Drug Release Abilities

Camptothecin-polylactide conjugates (CMPT-PLA) were synthesized by covalent incorporation of CMPT into PLA of different microstructure, i.e., atactic PLA and atactic-block-isotactically enriched PLA (P(m) = 0.79) via urethane bonds. The kinetic release of CPMT from CMPT-PLA conjugates, tested in vit...

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Detalles Bibliográficos
Autores principales: Oledzka, Ewa, Horeglad, Paweł, Gruszczyńska, Zuzanna, Plichta, Andrzej, Nałęcz-Jawecki, Grzegorz, Sobczak, Marcin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270997/
https://www.ncbi.nlm.nih.gov/pubmed/25429566
http://dx.doi.org/10.3390/molecules191219460
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author Oledzka, Ewa
Horeglad, Paweł
Gruszczyńska, Zuzanna
Plichta, Andrzej
Nałęcz-Jawecki, Grzegorz
Sobczak, Marcin
author_facet Oledzka, Ewa
Horeglad, Paweł
Gruszczyńska, Zuzanna
Plichta, Andrzej
Nałęcz-Jawecki, Grzegorz
Sobczak, Marcin
author_sort Oledzka, Ewa
collection PubMed
description Camptothecin-polylactide conjugates (CMPT-PLA) were synthesized by covalent incorporation of CMPT into PLA of different microstructure, i.e., atactic PLA and atactic-block-isotactically enriched PLA (P(m) = 0.79) via urethane bonds. The kinetic release of CPMT from CMPT-PLA conjugates, tested in vitro under different conditions, is possible in both cases and notably, strongly dependent on PLA microstructure. It shows that release properties of drug-PLA conjugates can be tailored by controlled design of the PLA microstructure, and allow in the case of CMPT-PLA conjugates for the development of highly controlled biodegradable CMPT systems—important delivery systems for anti-cancer agents.
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spelling pubmed-62709972018-12-28 Polylactide Conjugates of Camptothecin with Different Drug Release Abilities Oledzka, Ewa Horeglad, Paweł Gruszczyńska, Zuzanna Plichta, Andrzej Nałęcz-Jawecki, Grzegorz Sobczak, Marcin Molecules Communication Camptothecin-polylactide conjugates (CMPT-PLA) were synthesized by covalent incorporation of CMPT into PLA of different microstructure, i.e., atactic PLA and atactic-block-isotactically enriched PLA (P(m) = 0.79) via urethane bonds. The kinetic release of CPMT from CMPT-PLA conjugates, tested in vitro under different conditions, is possible in both cases and notably, strongly dependent on PLA microstructure. It shows that release properties of drug-PLA conjugates can be tailored by controlled design of the PLA microstructure, and allow in the case of CMPT-PLA conjugates for the development of highly controlled biodegradable CMPT systems—important delivery systems for anti-cancer agents. MDPI 2014-11-25 /pmc/articles/PMC6270997/ /pubmed/25429566 http://dx.doi.org/10.3390/molecules191219460 Text en © 2014 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Oledzka, Ewa
Horeglad, Paweł
Gruszczyńska, Zuzanna
Plichta, Andrzej
Nałęcz-Jawecki, Grzegorz
Sobczak, Marcin
Polylactide Conjugates of Camptothecin with Different Drug Release Abilities
title Polylactide Conjugates of Camptothecin with Different Drug Release Abilities
title_full Polylactide Conjugates of Camptothecin with Different Drug Release Abilities
title_fullStr Polylactide Conjugates of Camptothecin with Different Drug Release Abilities
title_full_unstemmed Polylactide Conjugates of Camptothecin with Different Drug Release Abilities
title_short Polylactide Conjugates of Camptothecin with Different Drug Release Abilities
title_sort polylactide conjugates of camptothecin with different drug release abilities
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270997/
https://www.ncbi.nlm.nih.gov/pubmed/25429566
http://dx.doi.org/10.3390/molecules191219460
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