A One-Step Microwave-Assisted Synthetic Method for an O/S-Chemoselective Route to Derivatives of the First Adenosine A3 PET Radiotracer

The synthesis of reference standards and expected in vivo metabolites of the first adenosine A3 PET radiotracer [(18)F]FE@SUPPY [(18)F]fluoroethyl 4,6-diethyl-5-[(ethyl-sulfanyl)carbonyl]-2-phenylpyridine-3-carboxylate) was achieved by using a straightforward microwave assisted alkylation method, wh...

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Detalles Bibliográficos
Autores principales: Shanab, Karem, Neudorfer, Catharina, Holzer, Wolfgang, Mitterhauser, Markus, Wadsak, Wolfgang, Spreitzer, Helmut
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271051/
https://www.ncbi.nlm.nih.gov/pubmed/24699149
http://dx.doi.org/10.3390/molecules19044076
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author Shanab, Karem
Neudorfer, Catharina
Holzer, Wolfgang
Mitterhauser, Markus
Wadsak, Wolfgang
Spreitzer, Helmut
author_facet Shanab, Karem
Neudorfer, Catharina
Holzer, Wolfgang
Mitterhauser, Markus
Wadsak, Wolfgang
Spreitzer, Helmut
author_sort Shanab, Karem
collection PubMed
description The synthesis of reference standards and expected in vivo metabolites of the first adenosine A3 PET radiotracer [(18)F]FE@SUPPY [(18)F]fluoroethyl 4,6-diethyl-5-[(ethyl-sulfanyl)carbonyl]-2-phenylpyridine-3-carboxylate) was achieved by using a straightforward microwave assisted alkylation method, which allowed O/S-chemoselective alkylation of the starting material 1 to give each target compound 2–8 in a single step.
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spelling pubmed-62710512019-01-02 A One-Step Microwave-Assisted Synthetic Method for an O/S-Chemoselective Route to Derivatives of the First Adenosine A3 PET Radiotracer Shanab, Karem Neudorfer, Catharina Holzer, Wolfgang Mitterhauser, Markus Wadsak, Wolfgang Spreitzer, Helmut Molecules Communication The synthesis of reference standards and expected in vivo metabolites of the first adenosine A3 PET radiotracer [(18)F]FE@SUPPY [(18)F]fluoroethyl 4,6-diethyl-5-[(ethyl-sulfanyl)carbonyl]-2-phenylpyridine-3-carboxylate) was achieved by using a straightforward microwave assisted alkylation method, which allowed O/S-chemoselective alkylation of the starting material 1 to give each target compound 2–8 in a single step. MDPI 2014-04-02 /pmc/articles/PMC6271051/ /pubmed/24699149 http://dx.doi.org/10.3390/molecules19044076 Text en © 2014 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Communication
Shanab, Karem
Neudorfer, Catharina
Holzer, Wolfgang
Mitterhauser, Markus
Wadsak, Wolfgang
Spreitzer, Helmut
A One-Step Microwave-Assisted Synthetic Method for an O/S-Chemoselective Route to Derivatives of the First Adenosine A3 PET Radiotracer
title A One-Step Microwave-Assisted Synthetic Method for an O/S-Chemoselective Route to Derivatives of the First Adenosine A3 PET Radiotracer
title_full A One-Step Microwave-Assisted Synthetic Method for an O/S-Chemoselective Route to Derivatives of the First Adenosine A3 PET Radiotracer
title_fullStr A One-Step Microwave-Assisted Synthetic Method for an O/S-Chemoselective Route to Derivatives of the First Adenosine A3 PET Radiotracer
title_full_unstemmed A One-Step Microwave-Assisted Synthetic Method for an O/S-Chemoselective Route to Derivatives of the First Adenosine A3 PET Radiotracer
title_short A One-Step Microwave-Assisted Synthetic Method for an O/S-Chemoselective Route to Derivatives of the First Adenosine A3 PET Radiotracer
title_sort one-step microwave-assisted synthetic method for an o/s-chemoselective route to derivatives of the first adenosine a3 pet radiotracer
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271051/
https://www.ncbi.nlm.nih.gov/pubmed/24699149
http://dx.doi.org/10.3390/molecules19044076
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