Cargando…

Synthesis and Biological Evaluation of Chromenylurea and Chromanylurea Derivatives as Anti-TNF-α agents that Target the p38 MAPK Pathway

A series of 1-aryl-3-(2H-chromen-5-yl)urea and 1-aryl-3-(chroman-5-yl)urea derivatives were designed, synthesized and evaluated for their inhibitory activities towards TNF-α production in lipopolysaccharide-stimulated THP-1 cells. The most active compound, 40g, inhibited TNF-α release with an IC(50)...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Xingzhou, Zhou, Xinming, Zhang, Jing, Wang, Lili, Long, Long, Zheng, Zhibing, Li, Song, Zhong, Wu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271066/ https://www.ncbi.nlm.nih.gov/pubmed/24531217 http://dx.doi.org/10.3390/molecules19022004

Ejemplares similares

Regulation of myogenic activation of p38 MAPK by TACE-mediated TNFα release
por: Li, Yi-Ping, et al.
Publicado: (2014)

TNFα alters occludin and cerebral endothelial permeability: Role of p38MAPK
por: Ni, Yawen, et al.
Publicado: (2017)

Design, Synthesis and Biological Evaluation of Novel Substituted N,N′-Diaryl ureas as Potent p38 Inhibitors
por: Zhu, Dianxi, et al.
Publicado: (2015)

Design, Synthesis, and Biological Evaluation of Tetra-Substituted Thiophenes as Inhibitors of p38α MAPK
por: Vinh, Natalie B, et al.
Publicado: (2015)

Sensitization of colonic nociceptors by TNFα is dependent on TNFR1 expression and p38 MAPK activity
por: Barker, Katie H., et al.
Publicado: (2022)

Cathepsin C Interacts with TNF-α/p38 MAPK Signaling Pathway to Promote Proliferation and Metastasis in Hepatocellular Carcinoma
por: Zhang, Guo-Pei, et al.
Publicado: (2020)

Microglial p38α MAPK is critical for LPS-induced neuron degeneration, through a mechanism involving TNFα
por: Xing, Bin, et al.
Publicado: (2011)

UVB-Stimulated TNFα Release from Human Melanocyte and Melanoma Cells Is Mediated by p38 MAPK
por: Muthusamy, Visalini, et al.
Publicado: (2013)

Inhibition of p38MAPK and CD137 signaling reduce dengue virus-induced TNF-α secretion and apoptosis
por: Nagila, Amar, et al.
Publicado: (2013)

Infiltrating macrophages in diabetic nephropathy promote podocytes apoptosis via TNF-α-ROS-p38MAPK pathway
por: Guo, Yinfeng, et al.
Publicado: (2017)

Increased sensitivity to TNF-α promotes keloid fibroblast hyperproliferation by activating the NF-κB, JNK and p38 MAPK pathways
por: Li, Qijie, et al.
Publicado: (2021)

Radiation-induced abscopal reproductive effect is driven by TNF-α/p38 MAPK/Rac1 axis in Sertoli cells
por: Hu, Songling, et al.
Publicado: (2021)

TNF-α stimulates System A amino acid transport in primary human trophoblast cells mediated by p38 MAPK signaling
por: Aye, Irving L M H, et al.
Publicado: (2015)

Antibacterial peptides inhibit MC3T3-E1 cells apoptosis induced by TNF-α through p38 MAPK pathway
por: Lu, Rong-Jian, et al.
Publicado: (2020)

Protective effect of KLF15 on vascular endothelial dysfunction induced by TNF-α
por: Liu, Bing, et al.
Publicado: (2018)

The Role of TNF-α and Anti-TNF-α Agents during Preconception, Pregnancy, and Breastfeeding
por: Romanowska-Próchnicka, Katarzyna, et al.
Publicado: (2021)

Structure-based design, synthesis and crystallization of 2-arylquinazolines as lipid pocket ligands of p38α MAPK
por: Bührmann, Mike, et al.
Publicado: (2017)

Autophagy in inflammation: the p38α MAPK-ULK1 axis
por: She, Hua, et al.
Publicado: (2018)

Impact of Myeloid p38α/MAPK on Orthodontic Tooth Movement
por: Kirschneck, Christian, et al.
Publicado: (2022)

High TNF-α and/or p38MAPK expression predicts a favourable prognosis in patients with T(1)N(0)M(0) hepatocellular carcinoma: An immunohistochemical study
por: Zhang, Mao, et al.
Publicado: (2019)

High TNF-α and/or p38MAPK expression predicts a favourable prognosis in patients with T1N0M0 hepatocellular carcinoma: An immunohistochemical study
por: Zhang, Mao, et al.
Publicado: (2019)

Transmembrane TNF-α: structure, function and interaction with anti-TNF agents
por: Horiuchi, Takahiko, et al.
Publicado: (2010)

TNF-α Regulates the Glucocorticoid Receptor Alpha Expression in Human Nasal Epithelial Cells Via p65-NF-κb and p38-MAPK Signaling Pathways
por: Jiang, Yongquan, et al.
Publicado: (2023)

NLS-RARα Inhibits the Effects of All-trans Retinoic Acid on NB4 Cells by Interacting with P38α MAPK
por: Xiao, Chunlan, et al.
Publicado: (2016)

p38 MAPK in MDS
por: Gañán‐Gómez, Irene, et al.
Publicado: (2015)

Modulation of the Nur77-Bcl-2 apoptotic pathway by p38α MAPK
por: Liu, Jie, et al.
Publicado: (2017)

Selective unresponsiveness to the inhibition of p38 MAPK activation by cAMP helps L929 fibroblastoma cells escape TNF-α-induced cell death
por: Wang, Jing, et al.
Publicado: (2010)

Geraniin inhibits TNF-α-induced impairments of osteogenesis through NF-κB and p38 MAPK signalling pathways in bone marrow stem cells
por: Lu, Chao, et al.
Publicado: (2017)

TNF-α acutely enhances acid-sensing ion channel currents in rat dorsal root ganglion neurons via a p38 MAPK pathway
por: Wei, Shuang, et al.
Publicado: (2021)

IL-35 inhibits cell pyroptosis and attenuates cell injury in TNF-α-induced bronchial epithelial cells via p38 MAPK signaling pathway
por: Wang, Yanbo, et al.
Publicado: (2022)

Age-dependent regulation of antioxidant genes by p38α MAPK in the liver
por: Pérez, Salvador, et al.
Publicado: (2018)

Biological agents targeting beyond TNF-alpha
por: Sharma, Rashmi, et al.
Publicado: (2008)

TNF-α Inhibitors and Other Biologic Agents for the Treatment of Immune Checkpoint Inhibitor-Induced Myocarditis
por: Liu, Xiaohang, et al.
Publicado: (2022)

Synthesis and Biological Activity of a VHL-Based PROTAC Specific for p38α
por: Cubillos-Rojas, Mónica, et al.
Publicado: (2023)

MPP8 Promotes Proliferation and Restrains Apoptosis in Osteosarcoma by Regulating p38αMAPK Pathway
por: Li, Tao, et al.
Publicado: (2021)

RACK1 antagonizes TNF-α-induced cell death by promoting p38 activation
por: Wang, Qingyang, et al.
Publicado: (2015)

p38 MAPK regulates PKAα and CUB-serine protease in Amphibalanus amphitrite cyprids
por: Zhang, Gen, et al.
Publicado: (2015)

TNF-α Induces Cytosolic Phospholipase A(2) Expression in Human Lung Epithelial Cells via JNK1/2- and p38 MAPK-Dependent AP-1 Activation
por: Lee, I-Ta, et al.
Publicado: (2013)

Targeted ablation of p38α MAPK suppresses denervation-induced muscle atrophy
por: Yuasa, Kazuki, et al.
Publicado: (2018)

Inhibition of Neuronal p38α, but not p38β MAPK, Provides Neuroprotection Against Three Different Neurotoxic Insults
por: Xing, Bin, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_aqtd7uohiapd7p5p0o0rob0g2j