Copaiba Oil Suppresses Inflammatory Cytokines in Splenocytes of C57Bl/6 Mice Induced with Experimental Autoimmune Encephalomyelitis (EAE)

Experimental autoimmune encephalomyelitis (EAE) is a murine autoimmune disease used to study multiple sclerosis. We have investigated the immunomodulatory effects of copaiba oil (100, 50 and 25 µg/mL) on NO, H(2)O(2), TNF-α, IFN-γ and IL-17 production in cultured cells from EAE-mice. Copaiba oil (10...

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Detalles Bibliográficos
Autores principales: Dias, Débora S., Fontes, Lívia B. A., Crotti, Antônio E. M., Aarestrup, Beatriz J. V., Aarestrup, Fernando M., da Silva Filho, Ademar A., Corrêa, José O. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271072/
https://www.ncbi.nlm.nih.gov/pubmed/25153880
http://dx.doi.org/10.3390/molecules190812814
Descripción
Sumario:Experimental autoimmune encephalomyelitis (EAE) is a murine autoimmune disease used to study multiple sclerosis. We have investigated the immunomodulatory effects of copaiba oil (100, 50 and 25 µg/mL) on NO, H(2)O(2), TNF-α, IFN-γ and IL-17 production in cultured cells from EAE-mice. Copaiba oil (100 µg/mL) inhibited H(2)O(2), NO, IFN-γ TNF-α and IL-17 production spontaneously or after ConA and MOG(35–55) stimulation. It is suggested that copaiba oil acts on the mechanism of development of EAE by IFN-γ, IL-17 and TNF-α inhibition, modulating the immune response on both Th1 and Th17 cells.

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