Copaiba Oil Suppresses Inflammatory Cytokines in Splenocytes of C57Bl/6 Mice Induced with Experimental Autoimmune Encephalomyelitis (EAE)

Experimental autoimmune encephalomyelitis (EAE) is a murine autoimmune disease used to study multiple sclerosis. We have investigated the immunomodulatory effects of copaiba oil (100, 50 and 25 µg/mL) on NO, H(2)O(2), TNF-α, IFN-γ and IL-17 production in cultured cells from EAE-mice. Copaiba oil (10...

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Autores principales: Dias, Débora S., Fontes, Lívia B. A., Crotti, Antônio E. M., Aarestrup, Beatriz J. V., Aarestrup, Fernando M., da Silva Filho, Ademar A., Corrêa, José O. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271072/
https://www.ncbi.nlm.nih.gov/pubmed/25153880
http://dx.doi.org/10.3390/molecules190812814
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author Dias, Débora S.
Fontes, Lívia B. A.
Crotti, Antônio E. M.
Aarestrup, Beatriz J. V.
Aarestrup, Fernando M.
da Silva Filho, Ademar A.
Corrêa, José O. A.
author_facet Dias, Débora S.
Fontes, Lívia B. A.
Crotti, Antônio E. M.
Aarestrup, Beatriz J. V.
Aarestrup, Fernando M.
da Silva Filho, Ademar A.
Corrêa, José O. A.
author_sort Dias, Débora S.
collection PubMed
description Experimental autoimmune encephalomyelitis (EAE) is a murine autoimmune disease used to study multiple sclerosis. We have investigated the immunomodulatory effects of copaiba oil (100, 50 and 25 µg/mL) on NO, H(2)O(2), TNF-α, IFN-γ and IL-17 production in cultured cells from EAE-mice. Copaiba oil (100 µg/mL) inhibited H(2)O(2), NO, IFN-γ TNF-α and IL-17 production spontaneously or after ConA and MOG(35–55) stimulation. It is suggested that copaiba oil acts on the mechanism of development of EAE by IFN-γ, IL-17 and TNF-α inhibition, modulating the immune response on both Th1 and Th17 cells.
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spelling pubmed-62710722018-12-27 Copaiba Oil Suppresses Inflammatory Cytokines in Splenocytes of C57Bl/6 Mice Induced with Experimental Autoimmune Encephalomyelitis (EAE) Dias, Débora S. Fontes, Lívia B. A. Crotti, Antônio E. M. Aarestrup, Beatriz J. V. Aarestrup, Fernando M. da Silva Filho, Ademar A. Corrêa, José O. A. Molecules Article Experimental autoimmune encephalomyelitis (EAE) is a murine autoimmune disease used to study multiple sclerosis. We have investigated the immunomodulatory effects of copaiba oil (100, 50 and 25 µg/mL) on NO, H(2)O(2), TNF-α, IFN-γ and IL-17 production in cultured cells from EAE-mice. Copaiba oil (100 µg/mL) inhibited H(2)O(2), NO, IFN-γ TNF-α and IL-17 production spontaneously or after ConA and MOG(35–55) stimulation. It is suggested that copaiba oil acts on the mechanism of development of EAE by IFN-γ, IL-17 and TNF-α inhibition, modulating the immune response on both Th1 and Th17 cells. MDPI 2014-08-21 /pmc/articles/PMC6271072/ /pubmed/25153880 http://dx.doi.org/10.3390/molecules190812814 Text en © 2014 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Dias, Débora S.
Fontes, Lívia B. A.
Crotti, Antônio E. M.
Aarestrup, Beatriz J. V.
Aarestrup, Fernando M.
da Silva Filho, Ademar A.
Corrêa, José O. A.
Copaiba Oil Suppresses Inflammatory Cytokines in Splenocytes of C57Bl/6 Mice Induced with Experimental Autoimmune Encephalomyelitis (EAE)
title Copaiba Oil Suppresses Inflammatory Cytokines in Splenocytes of C57Bl/6 Mice Induced with Experimental Autoimmune Encephalomyelitis (EAE)
title_full Copaiba Oil Suppresses Inflammatory Cytokines in Splenocytes of C57Bl/6 Mice Induced with Experimental Autoimmune Encephalomyelitis (EAE)
title_fullStr Copaiba Oil Suppresses Inflammatory Cytokines in Splenocytes of C57Bl/6 Mice Induced with Experimental Autoimmune Encephalomyelitis (EAE)
title_full_unstemmed Copaiba Oil Suppresses Inflammatory Cytokines in Splenocytes of C57Bl/6 Mice Induced with Experimental Autoimmune Encephalomyelitis (EAE)
title_short Copaiba Oil Suppresses Inflammatory Cytokines in Splenocytes of C57Bl/6 Mice Induced with Experimental Autoimmune Encephalomyelitis (EAE)
title_sort copaiba oil suppresses inflammatory cytokines in splenocytes of c57bl/6 mice induced with experimental autoimmune encephalomyelitis (eae)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271072/
https://www.ncbi.nlm.nih.gov/pubmed/25153880
http://dx.doi.org/10.3390/molecules190812814
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