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Synthesis and Cytotoxic Evaluation of a Series of 2-Amino-Naphthoquinones against Human Cancer Cells
The cytotoxicity of a series of aminonaphthoquinones resulting from the reaction of suitable aminoacids with 1,4-naphthoquinone was assayed against SF-295 (glioblastoma), MDAMB-435 (breast), HCT-8 (colon), HCT-116 (colon), HL-60 (leukemia), OVCAR-8 (ovarian), NCI-H358M (bronchoalveolar lung carcinom...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271085/ https://www.ncbi.nlm.nih.gov/pubmed/25162959 http://dx.doi.org/10.3390/molecules190913188 |
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author | de Moraes, Thiago A. P. Filha, Maria J. S. Camara, Celso A. Silva, Tania M. S. Soares, Bruno M. Bomfim, Igor S. Pessoa, Claudia Ximenes, George C. Silva Junior, Valdemiro A. |
author_facet | de Moraes, Thiago A. P. Filha, Maria J. S. Camara, Celso A. Silva, Tania M. S. Soares, Bruno M. Bomfim, Igor S. Pessoa, Claudia Ximenes, George C. Silva Junior, Valdemiro A. |
author_sort | de Moraes, Thiago A. P. |
collection | PubMed |
description | The cytotoxicity of a series of aminonaphthoquinones resulting from the reaction of suitable aminoacids with 1,4-naphthoquinone was assayed against SF-295 (glioblastoma), MDAMB-435 (breast), HCT-8 (colon), HCT-116 (colon), HL-60 (leukemia), OVCAR-8 (ovarian), NCI-H358M (bronchoalveolar lung carcinoma) and PC3-M (prostate) cancer cells and also against PBMC (peripheral blood mononuclear cells). The results demonstrated that all the synthetic aminonaphthoquinones had relevant cytotoxic activity against all human cancer lines used in this experiment. Five of the compounds showed high cytotoxicity and selectivity against all cancer cell lines tested (IC(50) = 0.49 to 3.89 µg·mL(−1)). The title compounds were less toxic to PBMC, since IC(50) was 1.5 to eighteen times higher (IC(50) = 5.51 to 17.61 µg·mL(−1)) than values shown by tumour cell lines. The mechanism of cell growth inhibition and structure–activity relationships remains as a target for future investigations. |
format | Online Article Text |
id | pubmed-6271085 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62710852018-12-27 Synthesis and Cytotoxic Evaluation of a Series of 2-Amino-Naphthoquinones against Human Cancer Cells de Moraes, Thiago A. P. Filha, Maria J. S. Camara, Celso A. Silva, Tania M. S. Soares, Bruno M. Bomfim, Igor S. Pessoa, Claudia Ximenes, George C. Silva Junior, Valdemiro A. Molecules Article The cytotoxicity of a series of aminonaphthoquinones resulting from the reaction of suitable aminoacids with 1,4-naphthoquinone was assayed against SF-295 (glioblastoma), MDAMB-435 (breast), HCT-8 (colon), HCT-116 (colon), HL-60 (leukemia), OVCAR-8 (ovarian), NCI-H358M (bronchoalveolar lung carcinoma) and PC3-M (prostate) cancer cells and also against PBMC (peripheral blood mononuclear cells). The results demonstrated that all the synthetic aminonaphthoquinones had relevant cytotoxic activity against all human cancer lines used in this experiment. Five of the compounds showed high cytotoxicity and selectivity against all cancer cell lines tested (IC(50) = 0.49 to 3.89 µg·mL(−1)). The title compounds were less toxic to PBMC, since IC(50) was 1.5 to eighteen times higher (IC(50) = 5.51 to 17.61 µg·mL(−1)) than values shown by tumour cell lines. The mechanism of cell growth inhibition and structure–activity relationships remains as a target for future investigations. MDPI 2014-08-26 /pmc/articles/PMC6271085/ /pubmed/25162959 http://dx.doi.org/10.3390/molecules190913188 Text en © 2014 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article de Moraes, Thiago A. P. Filha, Maria J. S. Camara, Celso A. Silva, Tania M. S. Soares, Bruno M. Bomfim, Igor S. Pessoa, Claudia Ximenes, George C. Silva Junior, Valdemiro A. Synthesis and Cytotoxic Evaluation of a Series of 2-Amino-Naphthoquinones against Human Cancer Cells |
title | Synthesis and Cytotoxic Evaluation of a Series of 2-Amino-Naphthoquinones against Human Cancer Cells |
title_full | Synthesis and Cytotoxic Evaluation of a Series of 2-Amino-Naphthoquinones against Human Cancer Cells |
title_fullStr | Synthesis and Cytotoxic Evaluation of a Series of 2-Amino-Naphthoquinones against Human Cancer Cells |
title_full_unstemmed | Synthesis and Cytotoxic Evaluation of a Series of 2-Amino-Naphthoquinones against Human Cancer Cells |
title_short | Synthesis and Cytotoxic Evaluation of a Series of 2-Amino-Naphthoquinones against Human Cancer Cells |
title_sort | synthesis and cytotoxic evaluation of a series of 2-amino-naphthoquinones against human cancer cells |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271085/ https://www.ncbi.nlm.nih.gov/pubmed/25162959 http://dx.doi.org/10.3390/molecules190913188 |
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