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Water Extract of Acer tegmentosum Reduces Bone Destruction by Inhibiting Osteoclast Differentiation and Function
The stem of Acer tegmentosum has been widely used in Korea for the treatment of hepatic disorders. In this study, we investigated the bone protective effect of water extract of the stem of Acer tegmentosum (WEAT). We found that WEAT inhibits osteoclast differentiation induced by receptor activator o...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271087/ https://www.ncbi.nlm.nih.gov/pubmed/24694651 http://dx.doi.org/10.3390/molecules19043940 |
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author | Ha, Hyunil Shim, Ki-Shuk Kim, Taesoo An, Hyosun Lee, Chung-Jo Lee, Kwang Jin Ma, Jin Yeul |
author_facet | Ha, Hyunil Shim, Ki-Shuk Kim, Taesoo An, Hyosun Lee, Chung-Jo Lee, Kwang Jin Ma, Jin Yeul |
author_sort | Ha, Hyunil |
collection | PubMed |
description | The stem of Acer tegmentosum has been widely used in Korea for the treatment of hepatic disorders. In this study, we investigated the bone protective effect of water extract of the stem of Acer tegmentosum (WEAT). We found that WEAT inhibits osteoclast differentiation induced by receptor activator of nuclear factor-κB ligand (RANKL), an essential cytokine for osteoclast differentiation. In osteoclast precursor cells, WEAT inhibited RANKL-induced activation of JNK, NF-κB, and cAMP response element-binding protein, leading to suppression of the induction of c-Fos and nuclear factor of activated T cells cytoplasmic 1, key transcription factors for osteoclast differentiation. In addition, WEAT inhibited bone resorbing activity of mature osteoclasts. Furthermore, the oral administration of WEAT reduced RANKL-induced bone resorption and trabecular bone loss in mice. Taken together, our study demonstrates that WEAT possesses a protective effect on bone destruction by inhibiting osteoclast differentiation and function. |
format | Online Article Text |
id | pubmed-6271087 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62710872019-01-02 Water Extract of Acer tegmentosum Reduces Bone Destruction by Inhibiting Osteoclast Differentiation and Function Ha, Hyunil Shim, Ki-Shuk Kim, Taesoo An, Hyosun Lee, Chung-Jo Lee, Kwang Jin Ma, Jin Yeul Molecules Article The stem of Acer tegmentosum has been widely used in Korea for the treatment of hepatic disorders. In this study, we investigated the bone protective effect of water extract of the stem of Acer tegmentosum (WEAT). We found that WEAT inhibits osteoclast differentiation induced by receptor activator of nuclear factor-κB ligand (RANKL), an essential cytokine for osteoclast differentiation. In osteoclast precursor cells, WEAT inhibited RANKL-induced activation of JNK, NF-κB, and cAMP response element-binding protein, leading to suppression of the induction of c-Fos and nuclear factor of activated T cells cytoplasmic 1, key transcription factors for osteoclast differentiation. In addition, WEAT inhibited bone resorbing activity of mature osteoclasts. Furthermore, the oral administration of WEAT reduced RANKL-induced bone resorption and trabecular bone loss in mice. Taken together, our study demonstrates that WEAT possesses a protective effect on bone destruction by inhibiting osteoclast differentiation and function. MDPI 2014-04-01 /pmc/articles/PMC6271087/ /pubmed/24694651 http://dx.doi.org/10.3390/molecules19043940 Text en © 2014 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Ha, Hyunil Shim, Ki-Shuk Kim, Taesoo An, Hyosun Lee, Chung-Jo Lee, Kwang Jin Ma, Jin Yeul Water Extract of Acer tegmentosum Reduces Bone Destruction by Inhibiting Osteoclast Differentiation and Function |
title | Water Extract of Acer tegmentosum Reduces Bone Destruction by Inhibiting Osteoclast Differentiation and Function |
title_full | Water Extract of Acer tegmentosum Reduces Bone Destruction by Inhibiting Osteoclast Differentiation and Function |
title_fullStr | Water Extract of Acer tegmentosum Reduces Bone Destruction by Inhibiting Osteoclast Differentiation and Function |
title_full_unstemmed | Water Extract of Acer tegmentosum Reduces Bone Destruction by Inhibiting Osteoclast Differentiation and Function |
title_short | Water Extract of Acer tegmentosum Reduces Bone Destruction by Inhibiting Osteoclast Differentiation and Function |
title_sort | water extract of acer tegmentosum reduces bone destruction by inhibiting osteoclast differentiation and function |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271087/ https://www.ncbi.nlm.nih.gov/pubmed/24694651 http://dx.doi.org/10.3390/molecules19043940 |
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