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Exploring the Phe-Gly Dipeptide-Derived Piperazinone Scaffold in the Search for Antagonists of the Thrombin Receptor PAR1

A series of Phe-Gly dipeptide-derived piperazinones containing an aromatic urea moiety and a basic amino acid has been synthesized and evaluated as inhibitors of human platelet aggregation induced by the PAR1 agonist SFLLRN and as cytotoxic agents in human cancer cells. The synthetic strategy involv...

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Detalles Bibliográficos
Autores principales:	Valdivielso, Ángel M., García-López, M. Teresa, Gutiérrez-Rodríguez, Marta, Herranz, Rosario
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271095/ https://www.ncbi.nlm.nih.gov/pubmed/24743938 http://dx.doi.org/10.3390/molecules19044814

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